δ,κ亚型阿片受体在促甲状腺素释放激素抗兔失血性休克中的作用  

The importance of δ and κ opioid receptors in the reversal of hemorrhagic shock in rabbits

作　　者：刘良明[1] 胡德耀[1] 卢儒权[1] 陈惠孙[1] 吴炎 

机构地区：[1]第三军医大学大坪医院野战外科研究所

出　　处：《中国病理生理杂志》1998年第2期118-121,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：目的和方法：用兔侧脑室给药观察了δ亚型阿片受体拮抗剂ＩＣＩ１７４，８６４和κ亚型阿片受体特异性拮抗剂ｎｏｒ－ｂｉｎａｌｔｏｒｐｈｉｍｉｎｅ（Ｎｏｒ－ＢＮＴ）预处理对促甲状腺素释放激素（ＴＲＨ）抗休克作用的影响。结果：ＴＲＨ（５０μｇ，ｉｃｖ）可明显升高失血性休克兔平均动脉压（ＭＡＰ），左室收缩压（ＬＶＳＰ），改善失血性休克心肌收缩力指标如心室内压最大上升和下降速率（±ｄｐ／ｄｔｍａｘ），心肌纤维收缩速度（Ｖｃｅ４０，Ｖｐｍ）和心肌收缩向量环面积（Ｌｏ）。δ－亚型阿片受体特异拮抗剂ＩＣＩ１７４，８６４预处理可取消ＴＲＨ的上述作用，κ－亚型阿片受体特异拮抗Ｎｏｒ－ＢＮＴ预处理不能取消ＴＲＨ的作用。结论：ＴＲＨ的抗休克作用与δ－亚型阿片受体有关。AIM and METHOD: The present study was aimed to investigate the importance of δ and κ opioid receptors in thyrotropin releasing hormone(TRH)against hemorrhagic shock in rabbits.Effects of pretreatment of ICI 174,864,a highly selective δ opioid receptor antagonist,and nor-binaltorphimine (Nor-BNI),a highly selective κ opioid receptor antagonist, on the property of TRH were observed.RESULTS:TRH(50μg,icv)could result in a marked increase of MAP,LVCP±dp/dtmax,Vce40,Vpm and Lo following hemorrhagic shock in rabbits.ICI174,864 pretreatment (50μg,icv)could abolish these effects of TRH,but,Nor-BNI pretreatment(50μg,icv)could not abrogate the TRH effect.CONCLUSION:The beneficial effects of TRH in the treatment of shock was closely related to δ opioid receptor,but not to κ Opioid receptor.δ opioid receptor plays an important mediating role in TRH against shock.

关 键 词：促甲状腺素释放激素 失血性休克 受体 兔 δ-亚型阿片受体 k-亚型阿片受体 

分 类 号：R605.971[医药卫生—急诊医学]