不同时间氟暴露对孕鼠甲状腺形态和功能的影响  

Effects of Fluorlde Exposure on the Thyroid's Morphology and Function of Mice in Pregnancy

作　　者：常青[1,2] 戎诚兴[1,2] 张世明 

机构地区：[1]暨南大学医学院 [2]湖北医科大学组胚教研室

出　　处：《微量元素与健康研究》1998年第2期10-12,共3页Studies of Trace Elements and Health

摘　　要：观察氟对孕鼠甲状腺形态和功能的影响。取受孕后（Ｐ１组）或受孕前１２周始（Ｐ２组）自由饮用２００ｍｇ／Ｌ含氟水小鼠的甲状腺和血清，观察其形态变化，测定血清甲状腺素（Ｔ４）水平。结果：Ｐ１组甲状腺呈增生性改变，血Ｔ４浓度显著高于对照组（Ｃ组，Ｐ＜０．００１）；Ｐ２组部分腺体呈退行性改变，血Ｔ４浓度与Ｃ组无差别（Ｐ＞０．０５）。提示：氟对孕鼠甲状腺的影响与作用时间有关。Aim Understanding the effects of fluoride on the morphology and function of thyroid glands of mice in pregnancy.Mice drank 200 mg/L fluoride solution freely during different terms.The morphology change were observed by light microscope and transmission electron microscope.The concentration of serum Thyroxine (T 4) were measured by Radioimmunoassay (RIA)Results:Shortterm flioriode administration results in 'hyperthyroidism' in morphology of thyroid glands,and thyroxine concentration raise significantly.Long term fluoride exposure induces the degerative change of thyroid glands partly.Conclution:The different of effects of fluoride on the thyroid of mice in pregnancy relate to the administration time of fluoride.

关 键 词：氟化物 甲状腺 妊娠小鼠 

分 类 号：R599.9[医药卫生—内科学] R714.147[医药卫生—临床医学]