肌梭传入在运动性通气增强反应中的作用  

Effects of Muscle Spindle Afferents on Increased Ventilatory Response to Exercise

作　　者：邢国刚[1] 樊小力[1] 霍涌玮[2] 宋新爱[1] 

机构地区：[1]西安交通大学医学院生理学教研室,710061 [2]西安交通大学医学院组织胚胎学教研室

出　　处：《中国运动医学杂志》2001年第2期129-131,共3页Chinese Journal of Sports Medicine

基　　金：陕西省卫生厅科学研究基金

摘　　要：在 6 3只麻醉、制动、断双侧迷走神经、人工呼吸的家兔中 ,以膈神经传出放电作为呼吸效应的客观指标 ,用琥珀胆碱 (Sch)选择性地兴奋肌梭 ,观察了肌梭传入在运动性通气增强反应中的作用。结果表明 :股动脉注射Sch后有 2 3例 (占 36 5 1% )产生吸气延长效应 ,表现为吸气时程 (Ti)延长 (P <0 0 5 ) ,呼气时程 (Te)有缩短趋势 ,但差异无显著性 ,Ti/Te比值增加 (P <0 0 5 ) ,肺通气量加大 ;17例 (占 2 6 98% )呈抑呼增频效应 ,表现为Te缩短 ,Ti变化不明显 ,Ti/Te比值增加 ,呼吸频率 (RF)加快 ,最终也导致肺通气量加大。肌注布比卡因破坏肌梭后 ,同剂量的Sch则使上述呼吸易化效应明显减弱。提示肌梭传入活动在运动性通气增强反应中具有重的作用。In 63 anesthetized,paralyzed,vagotomized and artificially ventilated rabbits,using the phrenic nerve discharges as the index of respiration,we observed the effects of muscle spindle afferents induced by intraarterial injection of succinylcholine (Sch) on increased ventilatory response to exercise.Results:There were 23(36 51%)cases which had the effect of prolongation of inspiratory phase due to the increase in inspiratory duration (Ti) and Ti/Te. Another 17(26 98%)cases had the effect of attenuated expiratory phase and augmented respiratory frequency.The above facilitated effects of Sch were significantly attenuated by intramuscular application of bupivacaine to destroy the muscle spindles.These results suggest that muscle spindle afferents may play an important role in the increased ventilatory response to exercise.

关 键 词：肌梭传入 运动性通气增强反应 膈神经传出放电 琥珀胆碱 布比卡因 

分 类 号：R87[医药卫生—运动医学]