酒精性肝病不同阶段血清胃泌素的变化研究  

Study on changes of serum gastrin concentration in different stages of alcoholic liver disease

作　　者：王国祥[1] 刘春荣[2] 

机构地区：[1]本钢总医院消化内科,辽宁本溪117000 [2]中国医科大学第一临床附属医院消化内科,辽宁沈阳110001

出　　处：《中国冶金工业医学杂志》2001年第2期70-71,共2页Chinese Medical Journal of Metallurgical industry

摘　　要：目的 :探讨酒精性肝病不同阶段血清胃泌素变化及其临床意义。方法 :采用胃泌素放射免疫测定盒测定大鼠酒精性肝病模型在不同病理阶段的血清胃泌素含量 ,并与对照组比较。结果 :模型组酒精性肝炎和肝纤维化期血清胃泌素含量明显升高 ,存在显著性差异 (P <0 0 5) ;而酒精性脂肪肝期血清胃泌素含量无差异 (P >0 0 5)。结论Objective:The variations of serum gastrin concentration were tested in every pathologic stage of alcoholic liver disease (ALD),and whether or not there were significances with regard to them in the clinical aspects.Methods:Serum gastrin concentration of rats were determined by radioimmunoassay in different pathologic stages of ALD.Results:Contrasted with the control,there were significant differences in two stages of alcoholic heptitis and alcoholic cirrhosis (P<0 05) and not in stage of alcoholic fatty liver (P>0 05).Conclusions:The determinations of serum gastrins play significant roles in observation of state and staging of ALD.

关 键 词：酒精性肝病 胃泌素 放射免疫测定 肝纤维化 酒精性肝炎 

分 类 号：R446.1[医药卫生—诊断学]