湖北地区抗-HCV阴性献血者丙型肝炎病毒核酸流行率研究(1993年～2000年)  

HCV RNA Prevalence in Anti - HCV Negative Donors in Hubei Area, 1993-2000

作　　者：赵国胜[1] 黄鹏[2] 周庆申[1] 孙丽君[2] 王军[1] 周剑英 何焰[1] 

机构地区：[1]黄石市中心血站输血研究所,435000 [2]湖北省临床检验中心,430000

出　　处：《国外医学（输血及血液学分册）》2001年第2期162-164,共3页Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)

基　　金：湖北省卫生厅重点科技资助项目

摘　　要：本文作者采用分子技术、首先用PCR-混合血清法对1993年～2000年间湖北地区库血中传播HCV的危险度进行了评估,提出各地采血应考虑当地献血人群HCV抗体流行率背景,对湖北地区抗-HCV阴性献血者进行HCV RNA监测结果表明:无偿献血者中HCV RNA阳性率为0.19％(1/520),显著性地低于定期供全血者中2.15％(45/2096)和定期供血浆者的7.29％(29/398)。湖北地区定期供血者HCV基因型主要为Ⅱ型。研究结果表明,HCV RNA检测用于献血者筛查对于最大限度控制输血传播HCV具有重要意义。In this paper, We evaluated the risks of HCV transmission in banking blood in Hubei area,China( 1993 - 2000). Polymerase chain reaction- sample mixed was used, which we initiated in 1994. Results shows: The positive rates of HCV RNA in volunteer donors(0. 19% , 1/520) were significant reduced, comparing with the paidwhole blood donors(2.15% ,45/2096) and/or the paid plasma donors(7.29% ,29/398). The genotyping of HCV were type II in this area. Therefore, we consider it is important screening donors combined with the local backgrounds of Anti - HCV prevalence. In order to reduce the risks of PT - HCV, we consider it is necessary to screen donors with HCV RNA testing.

关 键 词：丙型肝炎病毒 核酸 流行率 输血传播 献血者 聚合酶链反应 

分 类 号：R181.3[医药卫生—流行病学]