血脂水平与冠心病关系的病例对照研究  

A case-control study on serum lipoproteins and coronary heart disease

作　　者：黄久仪[1] 阎明晓[1] 徐德忠[1] 李良寿[1] 贾国良[2] 李兰荪[2] 石丘玲[1] 

机构地区：[1]第四军医大学预防医学系流行病学教研室,陕西西安710033 [2]第四军医大学西京医院心血管内科,陕西西安710033

出　　处：《第四军医大学学报》2001年第7期638-641,共4页Journal of the Fourth Military Medical University

摘　　要：目的　探讨血脂水平与冠心病发病的关系 .方法　选择住院确诊的冠心病患者 84例为病例组 ,排除冠心病的住院患者或健康体检者 16 3例为对照组 ,对两组的血脂水平、脂蛋白 (a)的均数进行比较 ,并用单因素和多因素分析计算危险因素的优势比 (OR)及 OR95 %可信限 (95 % CI) .结果　病例组的总胆固醇、三酰甘油、高密度脂蛋白水平分别为 4.13,1.79和 1.16 mm ol· L- 1 ,脂蛋白 (a)为 0 .38g· L- 1 ,而对照组血脂三项为 3.82 ,1.44和 1.34mmol· L- 1 ,脂蛋白 (a)为 0 .16 g·L- 1 ,两组间均有显著的统计学差异 (P<0 .0 5 ) ;单因素分析显示 :上述 4项指标的 OR值分别为 3.0 3,2 .42 ,3.76和 0 .2 1.多因素分析结果显示 :被筛选进入 L ogistic回归方程的变量分别为高密度脂蛋白、脂蛋白 (a)、胆固醇水平和每日吸烟量 .结论　吸烟和脂代谢紊乱是我国冠心病患者的主要危险因素 ,我国的胆固醇水平以国际统一标准作为正常值界限 ,标准过高 .这些线索将为我国冠心病危险因素的深入研究和冠心病防治策略的制定提供必要的参考依据 .AIM To investigate the relationship between serum lipoprotein and coronary heart disease (CHD). METHODS 84 CHD inpatients were selected as case group and 163 non-CHD persons from inpatients or healthy population were defined as control group. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-c) and Lipoprotein (a) (Lp (a)) were measured. RESULTS Means of TC, TG, HDL-c and Lp (a) in cases were 4.13 mmol·L -1 , 1.79 mmol·L -1 , 1.16 mmol·L -1 and 0.38 g·L -1 respectively, while means of those variable in controls were 3.82 mmol·L -1 , 1.44 mmol·L -1 , 1.34 mmol·L -1 and 0.16 g·L -1 . Differences between two groups were significan ( P <0.05). Uni-variable analysis indicated that elevation of TG, TC and Lp (a) and decrease of HDL-c were significantly related to risk of CHD with Odds Ratio (OR) of 3.03, 2.42, 3.76 and 0.21 respectively. Multi-variable analysis showed that HDL-c, TC, Lp (a) and consumption of cigarettes per-day were the variables being selected in Logistic equation. CONCLUSION Dislipidemia and cigarette smoking might be the major risk factors of coronary heart disease in China and in terms of TC disputed boundary, the international standard is too high for Chinese.

关 键 词：冠心病 危险因素 血脂 病例对照研究 

分 类 号：R541.4[医药卫生—心血管疾病]