药物累积法测定普通马钱子粉与超细马钱子粉的表观药动学参数  

Determination of Apparent Pharmacokinetics Parameter of Ordinary Powder and Fine Powder of Semen Strychni with Drug Cumulative Method

作　　者：黄芳[1] 郭立玮[1] 金万勤[1] 

机构地区：[1]南京中医药大学植物药研究与新药开发中心,江苏南京210029

出　　处：《南京中医药大学学报》2001年第3期162-163,共2页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省科委应用研究项目! (BJ9713 7)

摘　　要：目的　研究超细粉体技术对马钱子药物动力学参数的影响。方法　用药物累积法测定普通马钱子粉与超细马钱子粉ig时的表观药动学参数。结果　两种粉末均符合一室开放型模型 ,测得Tmax分别为 1.30h、0 .31h ;Cmax分别为131.2mg/kg、176 .5mg/kg ;CL分别为 0 .10 5 4mg/kg/h、0 .2 10 8mg/kg/h。结论　超细粉体技术既可加快、加大马钱子在体内的吸收 。OBJECTIVE To investigate into the effect of fine levigation technique on the pharmacokinetics parameter of Semen Strychni. METHOD Drug cumulative method was employed to determine the apparent pharmacokinetics parameter of ordinary powder and fine powder of Semen Strychni. RESULT Both kinds of powder conformed to the one-chamber open model, with Tmax being 1.30 h and 0.31 h respectively, Cmax being 131.2 mg/kg and 176.5 mg/kg respectively and CL being 0.105 4 mg/kg·h and 0.210 8 mg/kg·h respectively. CONCLUSION Fine levigation technique can promote both the absorption and removal of Semen Strychni in the body.

关 键 词：超细粉体 马钱子 表观药动学参数 药物累积法 

分 类 号：R285.5[医药卫生—中药学]