阿克他利与甲氨蝶呤治疗类风湿关节炎的比较  

Actarit vs methotrexate in treating rheumatoid arthritis

作　　者：杨艳萍[1] 沈霖[1] 谢晶[1] 周丕祺[1] 刘保平[1] 高兰[1] 

机构地区：[1]同济医科大学附属协和医院骨科研究室,湖北武汉430022

出　　处：《中国新药与临床杂志》2001年第3期177-181,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :比较阿克他利和甲氨蝶呤对类风湿关节炎 (RA)的疗效和安全性。方法 :12 0例RA病人随机分为 2组 ,阿克他利组 80例 ,口服阿克他利10 0mg ,tid× 12wk。甲氨蝶呤组 4 0例 ,口服甲氨蝶呤 10mg ,qw× 12wk。结果 :阿克他利组总有效率为 73% ,甲氨蝶呤组为 78% (P >0 .0 5)。不良反应发生率分别为 9%和 18% ,差异有显著意义 (P <0 .0 5)。结论 :阿克他利治疗类风湿关节炎的疗效与甲氨蝶呤相似 ,但在安全性方面明显优于甲氨蝶呤。AIM: To campare the therapeutic effects and security between actarit (MS 932) and methotrexate(MTX) in the treatment of rheumatoid arthritis(RA). METHODS: One hundred and twenty patients with RA were randomly divided into two groups. Eighty patients of actarit group receved actarit, 100 mg, po , tid for 12 wk. The other forty patients received methotrexate 10 mg, po , qw for 12 wk as control. RESULTS: The total effective rates were 73 % for actarit and 78 % for MTX ( P > 0.05). The adverse reactions were 9 % and 18 %( P <0.05). CONCLUSION: Actarit is as same as methotrexate in the therapeutic effect, but actarit is better than MTX in security.

关 键 词：类风湿关节炎 阿克他利 甲氨蝶呤 药物疗法 治疗 疗效比较 

分 类 号：R971.1[医药卫生—药品] R593.22[医药卫生—药学]