羟氯喹的眼科不良反应分析  

A analysis on adverse reactions of hydroxychloroquine in ophthalmology

作　　者：余碧娥[1] 方丽[1] 

机构地区：[1]上海医科大学附属华山医院皮肤科,上海200040

出　　处：《中国新药与临床杂志》2001年第3期235-236,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :了解羟氯喹在眼科的不良反应及其发生率。方法 :选择较长期 (疗程≥ 6mo)服用羟氯喹的病人 39例 ,进行眼科检查包括一些特殊的眼功能检查。结果 :39例中 3例 (8% )出现视野范围缩小 ,其中 1例伴有视敏度降低。这 3例服用羟氧喹累积剂量均大于 10 0g。结论 :本观察显示羟氯喹眼科不良反应的发生可能与累积剂量有关 ,表现为视野改变和视敏度降低。AIM: To study the adverse reactions of hydroxychloroquine (HCQ) in ophthalmology. METHODS: Thirty nine patients treated with HCQ for more than six months were performed ophthalmic examinations including some specifie retinal function tests. RESULTS: There were 3 patients (8%) who presented the visual fields was minified. The visual acuity of one patient was decreased. The cumulative doses of HCQ were more than 100 g in this three patients. CONCLUSION: The adverse reactions of HCQ in ophthalmology are related with the cumulative doses of HCQ. The expression is that the visual fields and visual acuity are decreased.

关 键 词：羟氯喹 抗疟药 眼科学 视野 视敏度 

分 类 号：R978.61[医药卫生—药品]