高血压合并动脉粥样硬化与大动脉缓冲功能关系的研究  

Study of relationship between atherosclerosis and large arterial buffering function in patients with essential hypertension

作　　者：王宏宇[1] 张维忠[2] 龚兰生[2] 胡大一[1] 

机构地区：[1]北京大学人民医院心内科,100044 [2]上海第二医科大学附属瑞金医院

出　　处：《中华心血管病杂志》2001年第4期206-209,共4页Chinese Journal of Cardiology

摘　　要：目的　研究高血压病 (EH)合并动脉粥样硬化患者大动脉缓冲功能的改变。方法　选择 3 13例EH患者 ,其中男性 2 3 0例 ,女性 83例 ,平均年龄 ( 5 8.5± 10 .1)岁。应用脉搏波速度 (pulsewavevelocity ,PWV)自动测量系统测定颈动脉 股动脉PWV作为反映大动脉节段扩张性的参数 ;B型超声对颈动脉进行扫查 ,动脉粥样硬化的定义为内膜 中层厚度≥ 1.3mm。颈动脉横断面顺应性和容积扩张性作为评价大动脉缓冲功能的指标。结果　 3 13例EH患者合并颈动脉粥样斑块者 12 0例。与未合并颈动脉粥样硬化患者相比 ,EH合并颈动脉粥样硬化患者收缩压 [( 14 9.76± 2 0 .2 0 )mmHg比( 14 1.62± 18.94 )mmHg]、脉压 [( 61.72± 18.94 )mmHg比 ( 5 2 .84± 14 .5 8)mmHg]和PWV[( 12 .91±2 .93 )m/s比 ( 10 .78± 2 .0 2 )m/s]显著升高 (P均 <0 .0 0 1) ;颈动脉横断面顺应性 [( 64.68± 4 0 .5 2 ) 10 -3·mm2 /mmHg比 ( 81.5 5± 63 .4 5 ) 10 -3·mm2 /mmHg]和容积扩张性 [( 1.71± 1.4 0 ) 10 -3·mmHg比( 2 .3 9± 2 .0 1) 10 -3·mmHg]显著降低 (P均 <0 .0 5 )。结论　EH合并颈动脉粥样硬化者大动脉弹性减退 ,缓冲功能显著降低。Objective To explore large arterial buffering function in patients with essential hypertension (EH) who suffered atherosclerosis. Methods 313 patients with were selected, 230 male, 83 female, mean age 58.5±10.1 years. Automatic pulse wave velocity (PWV) system was used to examine carotid-femoral PWV that acted as an index to reflect large arterial distensibility. B-mode ultrasound was applied to scan carotid artery, common carotid artery intima-media thickness ≥1.3 mm was defined as atherosclerosis. Carotid cross-sectional compliance and volume distensibility were also used as indices to reflect large arterial buffering function. Results Among 313 patients with EH 120 presented carotid atherosclerosis. Systolic blood pressure (149.76±20.20 mm Hg vs 141.62±18.94 mm Hg), pulse pressure (61.72±18.94 mm Hg vs 52.84±14.58 mm Hg ) and PWV (12.91±2.93m/s vs 10.78±2.02 m/s) in EH patients with carotid atherosclerosis were significantly higher (P<0.001, respectively) and cross-sectional compliance of carotid artery (64.68±40.52 10 -3·mm2/mm Hg vs 81.55±63.45 10 -3·mm2/mm Hg) and volumic distensibility (1.71±1.40 10 -3·mm Hg vs 2.39±2.01 10 -3·mm Hg) were significantly lower (P<0.001, respectively) than those in patients without carotid atherosclerosis. Conclusion Large arterial elasticity and buffering function decreased in EH patients with carotid atherosclerosis.

关 键 词：高血压 动脉粥样硬化 大动脉缓冲功能 

分 类 号：R544.1[医药卫生—心血管疾病] R543.5[医药卫生—内科学]