电针对佐剂性关节炎大鼠脾细胞IL-1和IL-2活性的影响  

Effect of Electro acupuncture on Activity of IL-1 and IL-2 in Spleen Cell in Adjuvant Arthritis Rat

作　　者：赵仓焕[1] 王虹英[2] 杨介宾[3] 宋开源[3] 罗永芬[3] 梁繁荣[3] 

机构地区：[1]暨南大学医学院第一附属医院针灸科,广州510630 [2]上海市针灸经络研究所,上海200030 [3]成都中医药大学针推学院,四川610075

出　　处：《上海针灸杂志》2001年第2期34-36,共3页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的　为了探讨电针 (EA)对炎症痛镇痛的外周机制 ,观察 EA对佐剂性关节炎 (AA)大鼠脾细胞中细胞因子白细胞介素 1(IL- 1)和白细胞介素 2 (IL- 2 )活性的影响。方法　用福氏完全佐剂造成佐剂性关节炎 ,电针刺激悬钟和昆仑穴 ,用 H3- Td R掺入法和 MTT显色法分别检测 IL - 1和 IL - 2的活性。结果　 EA对 AA大鼠镇痛的同时 ,能够提高细胞因子 IL - 1和 IL - 2的活性。结论　 EA对炎症痛镇痛的外周机制与其提高细胞因子 IL - 1和 IL - 2的活性有关。Objective To probe into peripheral mechanism of electroacupuncture (EA) analgesia, the effect of EA on acitivity of IL 1 and IL 2 in spleen cell in adjuvant arthritis (AA) rat was observed. Methods Freund's complete adjuvant was injected into the right hind paw of art to establish adjuvant arthritis model, then the rat's acupoints Xuanzhong (GB 39) and Kunlun (BL 60) were given EA stimulation, and the H 3 TdR incorporation method and MTT development process were adopted to detect the activity of IL 1 and IL 2. Results EA may not only exert analgesic effect on AA rat, but also raise the activity of IL-1 and IL-2 in spleen cell. Conclusions The peripheral mechanism of EA analgesia is related to raising the activity of cellular factors IL-1 and IL-2.

关 键 词：佐剂性关节炎 白细胞介素1 白细胞介素2 镇痛 电针疗法 实验研究 

分 类 号：R246.9[医药卫生—针灸推拿学]