铁筷子多糖抑制小鼠体内S180生长作用及其机制的实验研究  

Experiment investigation of inhibitory mechanism on growth of S180 in mice by Tiekuaizi polysaccharide

作　　者：刘昕[1] 杨林西[2] 潘兴斌[1] 王晶宇[1] 

机构地区：[1]兰州医学院病理生理教研室,兰州730000 [2]兰州医学院生化教研室

出　　处：《中国现代应用药学》2001年第2期94-96,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：1997年甘肃省自然科学基金资助项目!编号ZR -97-0 6 9

摘　　要：目的 :研究铁筷子多糖 (HFPS)的体内抑瘤效应 ,探讨其作用机制。方法 :在动物模型上对比观察HFPS对S180生长的抑制作用 ,同时对动物免疫器官指数、脾淋巴细胞转化率和IL 2的水平、腹腔巨噬细胞I(PM )内酸性磷酸酶 (ACP)和精氨酸酶(ARG)的活性及巨噬细胞的吞噬功能进行了检测。结果 :用HFPS持续灌胃两周 ,可明显抑制S180的生长 ,动物免疫器官重量增加、细胞免疫功能增强 ,PM内酶活性增加、吞噬能力增强。结论 :HFPS对体内生长的肿瘤S180具有良好的抑制作用 ,其机制与促进机体免疫功能有关。OBJECTIVE:Study the inhibitory effect and the mechanism of helleborus thibetanus france.Polysaccharide(HFPS) on tumor growth.METHOD:The inhibitory function of HFPS to S180 was observed on animal model、The indexes of immunity organs,the rate of HFPS to S180 was observed on animal model.The indexes of immunity organs,the rate of splenic lymphocytes transformation,the level of IL 2,the ACP andarginase(ARG) vitality in PMand the swallowing fuction of M were all determined at same time.RESULTS:When HFPS was given for two weeks,the growth of S180 was restricted,while immunity organs weight,the cellular immunity function,the vitality of ACP and arginase in PM and the swallowing ability of M were heightened.CONCLUSION:HFPS could inhibit tumor S180 growth effectively in vivo,this mechanism was related to the affect that HFPS had promoted the immunity function.

关 键 词：铁筷子多糖 肿瘤 细胞免疫 腹腔巨噬细胞 实验研究 

分 类 号：R285.5[医药卫生—中药学]