毛细管区带电泳法测定复方磺胺甲噁唑片中两组分的含量  

Determination of two constituents in compound sulfamethoxazole tablets by capillary zone electrophoresis

作　　者：王桂芳[1] 张守尧[1] 沈霞[1] 

机构地区：[1]第一军医大学珠江医院,广州510282

出　　处：《西北药学杂志》2001年第2期51-52,共2页Northwest Pharmaceutical Journal

摘　　要：建立毛细管区带电泳法测定复方磺胺甲口恶唑片中磺胺甲口恶唑和甲氧苄啶含量的方法。用 2 5mmol/L硼砂缓冲液分离 ,以氯霉素为内标 ,2 14nm为测定波长。结果 :样品中二组分完全分离且呈良好线性关系 ,加样回收率分别为 10 1.0 % ( RSD =1.4 3% ) ,10 0 .3% ( RSD =1.2 8% )。To establish a capillary zone electrophoresis method for the assay of compound sulfamethoxazole tablets. The buffer used was borax solution(25mmol/L). The internal standard was chloramphenicol and the detective wavelength was 214nm. Sulfamethoxazole and trimethoprim were separated completely. The average recoveries were 101 0%(RSD=1 43%) and 100 3%(RSD=1 28%) respectively.

关 键 词：毛细管区带电泳法 复方磺胺甲恶唑片 磺胺甲恶唑 甲氧苄淀 含量测定 

分 类 号：R978.2[医药卫生—药品] R927.2[医药卫生—药学]