水痘一带状疱疹病毒分离株核衣壳的形态特征  

Morphological Characteristics of Nucleocapsids of Varicella-Zoster Virus Strain J(?)

作　　者：王志玉[1] 王桂亭[1] 韩世杰[1] 王少军[2] 宋伟涛[2] 谢慰杖 

机构地区：[1]山东医科大学病毒研究室,济南250012 [2]山东省卫生防疫站电镜室,济南250014

出　　处：《中国病毒学》1993年第1期39-44,共6页Virologica Sinica

摘　　要：本文用超薄切片电镜技术对水痘一带状疱疹病毒(VZV)分离株J_1的核衣壳进行了形态学研究。结果表明,在病毒感染后5小时即可观察到细胞核内大量的病毒核心相关颗粒和少量核衣壳。在细胞核内和细胞浆内均可见到病毒基质或毒浆结构。VZVJ_1株具有三种类型的核衣壳,命名为A型、B型、C型核衣壳。A型具有电子致密核心,B型的核心呈颗粒状,C型具有电子透明核心。三种核衣壳大小一致,直径75—100nm,核心为35—55nm。将VZV的核衣壳与疱疹病毒科其它成员作了比较分析,并对各种核衣壳在病毒成熟过程中的作用进行了探讨。The nucleocapsids of varicella-zoster virus (VZV) strain J1 isolated hy Dr. Hun Shi-jie et al in Jinan in 1990 were studied with electron microscope. Three distinct species of nucleocapsids of VZV strain Jl designated as either A, B or C on the basis of their electron densities, were cheracterized. Type A, B and C nucleocapsids possess a densely stained core, particleshaped core and light or empty core respectively. The nucleocapsids are 75—100nm and cores are 35—55nm in diameter. All the three species were not only seen in nuclei but also in cytoplasms. At the same time, viromatrices or viroplasts which are possibly made of viral capsomeres, were observed in nuclei and (?)ytoplasms. All the species appeared at 5h postinfection and the ratio of A:B: C was 30:45:25 in nuclei and 60:10:30 in cytoplasms. The relationship among them and their roles in viral maturation process were discussed. Based on the evidence accumulated in this study and previous data, the nucleocapsids are sligntly different from those of other herpesviruses.

关 键 词：水痘-带状疱疹病毒 核衣壳 形态学 

分 类 号：R373.1[医药卫生—病原生物学]