EHF灭活疫苗扩大人体试用的效果观察  

Efficacy of Inactivated EHF Vaccine Used in Clinical Trial

作　　者：朱智勇[1] 曾蓉芳[2] 俞永新[3] 

机构地区：[1]浙江省卫生防疫站,杭州310009 [2]上海生物制品研究所,上海200052 [3]中国药品生物制品检定所,北京100050

出　　处：《中国病毒学》1991年第4期315-319,共5页Virologica Sinica

摘　　要：流行性出血热(EHF)沙鼠肾细胞灭活疫苗,经75名自愿者扩大试用,未发现不良反应。中和抗体阳转率达70.6～96.7％,4℃保存14个月的疫苗,仍有较高的中和抗体阳转率,再一次证明此疫苗是安全有效的,且有良好的稳定性。接种程序为0、7、28天内三次免疫与0、28、60天内三次免疫无明显差别。皮下接种佐剂苗产生的中和抗体滴度高于肌肉接种的佐剂苗和疫苗。The inactivated EHF vaccine was used inclinincal trial with 75 volunteers. There was not any side effects. It showed that abaut 90% seroconversion rate of neutraliztion antibody occurred. The vaccine stored for 14 months in 4℃ still had better immunogenicity. It was shown for the second time that the vaccine was safe, affeetive and very stable. The immunization procedure of 3×1ml during 28 days and of 3×1ml during 60 days showed no significant difference.

关 键 词：EHF灭活疫苗 人体试用 免疫效果 

分 类 号：R512.8[医药卫生—内科学] R373.32[医药卫生—临床医学]