保存温度和时间对狂犬病疫苗效力稳定性的影响  

The effect of keeping temperature and time on the stability of potency of rabies vaccine

作　　者：陈怀恭[1] 张军哲[1] 梁勇[1] 安静[1] 朱莉萍[1] 

机构地区：[1]兰州生物制品研究所,兰州730046

出　　处：《微生物学免疫学进展》2001年第2期30-33,共4页Progress In Microbiology and Immunology

摘　　要：对人用精制狂犬病疫苗和浓缩狂犬病疫苗分别在 - 33℃ ,2～ 8℃ ,2 5℃ ,37℃保存 0～ 6个月进行效力的稳定性观察 ,结果表明随存放时间延长及温度增加 ,两者的生物活性均有不同程度的降低。在 2～ 8℃条件下疫苗的效力明显比其它温度稳定 (P <0 0 2 ) ;精制疫苗与浓缩疫苗比较 。The investigation was carried out on the stability of potency of purified and concentrated rabies vaccines for human use within six months storge period at -33℃,4℃,25℃ and 37℃ separately.the results indicated that the biological activties of both vaccines were decreased as the keeping temperature increased or stored time prolonged.A conclusion could then be drawn that the potencies of both vaccines have a remarkable higher stability at 4℃ than those at other different temperatures,and the former has a high stable trend than others do.

关 键 词：精制狂犬病疫苗 浓缩狂犬病疫苗 效力稳定性 保存温度 保存时间 

分 类 号：R392-33[医药卫生—免疫学]