卵巢、子宫肌层组织及静脉血中氧自由基代谢与子宫内膜异位症、子宫腺肌病发病的关系  

Correlation of the metabolism of oxygen free radical in ovary, uterine muscle and vein blood with the pathogenesis of endometriosis or endometrioma

作　　者：赵莲茹[1] 赵文霞[1] 欧玉清[2] 曹丽秋[1] 陈立平[1] 邢继强[2] 

机构地区：[1]黑龙江省佳木斯市中心医院妇产科,154002 [2]佳木斯大学基础医学院

出　　处：《中华妇产科杂志》2001年第5期299-301,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨氧自由基与子宫内膜异位症 (内异症 )、子宫腺肌病 (腺肌病 )发病的关系。方法　 (1)测定 32例卵巢内异症手术患者 (内异症组 )的静脉血 ,卵巢囊肿组织及囊液中脂质过氧化物 (LPO)、微量元素硒 (Se)、超氧化物歧化酶 (SOD)、维生素E(VE)的水平 ;(2 )测定 2 3例腺肌病手术患者 (腺肌病组 )的静脉血、子宫肌层组织的LPO、Se、SOD、VE的水平。另外选取 30例单纯子宫肌瘤患者作为对照 (对照组 )。结果　 (1)内异症组静脉血、卵巢组织中LPO水平为 (6 35 7± 1 2 5 1) μmol/L、(3 735± 1 5 46 )nmol/g蛋白 ,高于对照组的 (3 5 47± 1 6 40 ) μmol/L、(1 10 5± 0 6 5 3)nmol/g蛋白 (P<0 0 1) ;Se、SOD、VE水平均低于对照组 (P <0 0 1～ 0 0 5 )。 (2 )内异症组卵巢囊液中LPO水平高于自身静脉血及对照组静脉血 (P <0 0 1) ;(3)腺肌病组静脉血及子宫层肌组织LPO水平为 (5 882±1 711) μmol/L及LPO水平 (2 937± 1 5 77)nmol/g蛋白 ,高于对照组的 (3 5 47± 1 6 40 ) μmol/L及(1 75 4± 0 833)nmol/g蛋白 (P <0 0 1) ;静脉血Se、VE、SOD水平均低于对照组 (P <0 0 1) ;子宫肌层组织中Se、VE水平低于对照组 (P <0 0 1) ,而子宫肌层组织中SOD水平与对照组比较 ,差异无显著性(P >0 0 5 )Objective To investigate the correlation of metabolism disturbance of oxygen free radical(OFR) with endometriosis and endometrioma, to provide an evidence for the diagnosis and treatment. Methods (1) The lipid peroxide (LPO), selenium (Se), superxide dismutase (SOD) and vitamine E (VE) levels were respectively in the vein blood, ovary tissue of the chocolate cyst wall and chocolate cyst fluid in 32 operated patients with endometriosis (endometriosis group). (2) The levels above were determined seperately in 23 operated patients with endometrioma (endometrioma group) and 30 cases of hysteroma (control group). Results (1)The LPO levels in vein blood and ovary tissue of endometriosis group were (6 357±1 251) μmol/L and (3 735±1 546) nmol/g protein. Which significantly higher than those of control group ( P <0 01). On the other hand, the Se. SOD. VE levels in endometriosis group were significantly lower than those in control group ( P <0 01～ <0 05). (2) The LPO level in ovary chocolate cyst fluid was higher than that in vein blood itself and control group. ( P <0 01). (3) The LPO levels in vein blood and uterine muscle of endometrioma was (5 882±1 711) μmol/L and (2 937±1 577) nmol/g protein, they were higher than these in control group (3 547±1 640) μmol/L, (1 754±0 833) nmol/g protein, ( P <0 01). While, the Se. VE. SOD level tween the SOD level in uterine muscle tissue of endometriomin vein blood is significantly higher than those in control group ( P <0 01) . There is no difference bea and control group ( P >0 05). Conclusion The endome triosis and endometrioma is related to the produce or metabolistic inbalance of oxygen free radical, and so to the increasing of lipid peroxide.

关 键 词：子宫内膜异位症 子宫腺肌瘤 氧自由基 

分 类 号：R711.71[医药卫生—妇产科学] R737.33[医药卫生—临床医学]