血清TPO-Ab测定的临床应用  

Clinical Appliance of Anti-TP0-Ab in Blood Serum Determination

作　　者：王伯龄[1] 卫江亮[1] 谭波[1] 

机构地区：[1]昆明医学院第一附属医院核医学科,昆明650032

出　　处：《昆明医学院学报》2001年第2期46-47,53,共3页Journal of Kunming Medical College

摘　　要：甲亢患者、甲状腺肿大者、非甲状腺疾病患者测定血清TPO -Ab含量 .结果 :阳性率分别为78 5 % ,2 8 5 % ,3 33 % .甲亢组与非甲状腺疾病组的阳性率进行统计学处理 ,P <0 0 1,差异有非常显著性 .甲状腺肿大组与非甲状腺疾病的阳性率进行统计学处理 ,P <0 0 5 ,差异有显著性 .证明大部分甲亢患者血清TPO -Ab增高 ,甲状腺肿仅少数TPO -Ab升高 ,可能与桥本氏甲状腺肿有关 ,桥本氏甲状腺炎是一种自身免疫性疾病 ,患者体内产生TG -Ab (抗甲状腺球蛋白抗体 )和TM -Ab (抗甲状腺微粒体抗体 ) ,TPO -Ab又归类为抗微粒体抗体 (TM -Ab) ,所以 ,桥本氏甲状腺肿TPO -Ab升高 .结果表明 :TPO -Ab是一种自身免疫性抗体 ,它的应用为临床医师诊断、治疗、研究甲状腺疾病的病因提供了一种重要方法 .Graves disease, 21 thyroid enlargement,30 nonthyroid disease were determined anti-thyroid peroxidase antibody (anti-TPO-Ab) in blood serum. Electropositive ratio were 78 5% and 28 5% and 3 33%. There was significant difference (P<0 01) between Graves disease group and non-thyroid disease. There was a significant difference (P<0 05) between thyroid enlargement group and non-thyroid disease, which proves a majority of Graves disease anti-TPO-Ab increased. Hashimotos thyroiditis anti-TPO-Ab increase, because, anti-TPO-Ab was referred to as anti microsomal antibodies (TM-Ab).

关 键 词：TPO-AB 甲状腺功能亢进 桥本氏甲状腺炎 血清诊断 

分 类 号：R581[医药卫生—内分泌] R446.112[医药卫生—内科学]