犬冠状动脉和脑动脉多巴胺受体亚型对比研究  

Comparative studies on the characteristics of dopamine receptors in canines' coronary and cerebral arteries

作　　者：王毅[1] 朱琳[2] 郑丽丽 赵荣瑞[4] 

机构地区：[1]河南医科大学第一附属医院内科,郑州450052 [2]河南医科大学第一附属医院药剂科,郑州450052 [3]郑州460医院心内科,郑州450007 [4]山西医科大学生理学教研室,太原030001

出　　处：《河南医科大学学报》2001年第3期244-246,共3页Journal of Henan Medical University

基　　金：国家自然科学基金资助项目!3 92 3 0 15 0

摘　　要：目的 :对比分析犬冠状动脉和脑动脉多巴胺 (DA)受体亚型类别与反应特性。方法 :利用离体血管微量生物反应检测技术 ,测定多巴胺 1(DA1)受体激动剂非诺多泮 (Fenoldopam ,FODA)和多巴胺 2 (DA2 )受体激动剂propy lbutyl dopamine(PBDA)对冠状动脉和脑动脉血管环的舒张反应。结果 :①冠状动脉和脑动脉均有DA1受体分布 ,但其分布密度存在明显差别 ;②脑动脉内既有DA1受体又有DA2 受体分布 ;③用 6 羟多巴胺 (6 OHDA)处理后的实验进一步证实脑动脉存在有DA2 受体。结论 :冠状动脉和脑动脉DA受体亚型存在明显的异质性 ,阐明这种异质性将有助于了解多巴胺受体对冠脉循环和脑循环的不同生理反应。Aim:To study the (DA) receptor subtypes and functional significance in canine coronary and cerebral arteries.Methods:Vascular ring technique was used for determining vasorelaxing response to fenoldopam and PBDA in canine coronary and cerebral arteries.Results:①DA 1 receptors were distributed in the coronary and cerebral arteries,however,a great variation in their functional potency existed;②DA 2 receptors were only present in the cerebral artery. Conclusion:To clarify the heterogeneity in subtype and responsiveness of DA receptors in the coronary and cerebral arteries may help to evaluate the physiological signifiance of DA receptors.

关 键 词：犬 多巴胺受体 血管舒张 冠状动脉 脑动脉 

分 类 号：R331.3[医药卫生—人体生理学] R392.1[医药卫生—基础医学]