埋入5-氟尿嘧啶植入剂后家兔血清及肌肉组织中药物浓度的测定  

DETERMINATION OF DRUG CONCENTRATION IN SERUM AND MYOIDEUM AFTER 5-FLUOROURACIL IMPLANTS WERE IMPLANTED IN RABBIT

作　　者：徐子猷[1] 陈纪岳[1] 郁韵秋[1] 吴怀瑛[1] 王毅翔 徐红蓉 

机构地区：[1]上海医科大学药学院物理化学教研室,上海200032 [2]华山医院放射科,上海200040

出　　处：《中国临床药学杂志》1997年第2期77-79,共3页Chinese Journal of Clinical Pharmacy

摘　　要：埋入5-氟尿嘧啶(5-Fu)植入剂后.用高效液相色谱法测定家兔血清中及埋植处肌肉组织的药物浓度.结果表明:埋入植入剂后,5-Fu在体内能缓慢、恒定、长时间地释放,使埋植处局部维持较高浓度.而血药浓度长期稳定在较低范围.因此,该剂型的研制对于提高5-Fu的抗肿瘤疗效,降低其毒性具有积极的意义.Drug concentration in serum and myoideum around the implanting sites were measured by HPLC after 5-fluorouracil implants were implanted in the paravertebral muscles of rabbits. It was concluded that 5-Fu implants can release slowly,stably and persistently. Drug concentration in myoideum around the implanting sites can maintain at a higher level, however that in serum at consistently lower range. So the preparation of dosage form will be expected to improve the antineoplastic therapeutic effects and decrease the toxicity of 5-Fu.

关 键 词：5-氟尿嘧啶 植入剂 硅橡胶 高效液相色谱法 药物浓度 

分 类 号：R979.12[医药卫生—药品] R969.1[医药卫生—药学]