妊高征患者外周血红细胞内钙含量测定及其临床价值  

Study of alterations in intracellular free calcium of erythrocyte in women with induced hypertension

作　　者：尹格平[1] 郝天羽[1] 袁玮[1] 陈铭[1] 杨树君[1] 陈诵芬[1] 

机构地区：[1]济南军区总医院,250031

出　　处：《中国优生与遗传杂志》2001年第2期20-21,共2页Chinese Journal of Birth Health & Heredity

基　　金：全军"九五"科研基金项目!(基金编号 :98D0 16)

摘　　要：目的 :探讨不同程度妊高征血红细胞内Ca2 + 含量 (IECa[2 + ] 及病理机制、危害和对策。方法 :应用Fluo - 3/AM导入红细胞经流式细胞术检测IECa[2 + ] 的方法、对 37例不同程度的妊高征患者IECa2 + 进行定量测定 ,并研究与疾病程度和胎儿宫内窘迫发生关系。结果 :轻度妊高征产前及产时IECa2 + 含量与正常妊娠无显著性差异 (P >0 .0 5 ) ,中、重度姓高征者增加。具体表现为 :妊高征患者IECa2 + 含量显著高于正常妊娠 ,且产时较产前显著性增多 (P <0 .0 5 ,P <0 .0 1) ;IECa2 + 含量与妊高征患者平均动脉压 (MAP)呈正相关系。结论 :采取有效的降压措施是使IECa2 + 含量趋于正常水平以减低其危害的主要对策。Objective:To investigate the intracellular free calcium concentration in peripheral erythrocyte (IECa 2+ )and the clinical-pathological significance in women with pregnancy induced hypertension(PIH).Methods:Thirty-seven women with PIH were studied their IECa 2+ levels using a new indicator named Flo-3/AM by flow cytometry,and 32 women with normal pregnancy as control.Results:The IECa 2+ levels in severe PIH showed statistically higher than that in slight ones and the controls (P<0.05,P<0.01).The overlord of IECa 2+ also showed obvious relation to the degree of PIH and intrauterine asphyxia (P<0.05).Conclusions:The IECa 2+ level can reflect the severity degree of PIH.The best method to decrease the harmfulness as result of overload IECa 2+ is dropping hypertension by effective measure.

关 键 词：并发症 红细胞 钙离子 胎儿宫内窘迫 妊高征 

分 类 号：R714.246[医药卫生—妇产科学] R714.43[医药卫生—临床医学]