自然流产妇女血清及子宫内膜丙二醛和超氧化物歧化酶含量变化的研究  

Study on the relationship of spontaneous abortion to malondialdehyde and superoxide dismutase in sera and endometrium

作　　者：张萍[1] 王霞[1] 严敦清[2] 

机构地区：[1]青岛市市立医院,266011 [2]青岛医学院附属医院

出　　处：《中国优生与遗传杂志》2001年第2期28-29,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的 :主要研究自然流产妇女血清及子宫内膜组织中丙二醛 (MDA)、超氧化物歧化酶 (SOD)的变化。方法 :随机选择有自然流产史妇女 2 0例 (病理组 )、正常早孕和非孕妇女各 2 0例 (对照组 )。结果 :①自然流产组血清中MDA含量与对照组间无明显差异 (P >0 .0 5 )。子宫内膜组织中MDA含量自然流产组却明显高于对照组 (P <0 .0 1)②血清及子宫内膜组织中 ,自然流产组SOD含量明显低于对照组 (P <0 .0 1)。②血清及子宫内膜组织中 ,自然流产组SOD含量明显低于对照组 (P<0 .0 1)。③子宫内膜组织 ,SOD含量与自然流产次数呈负相关 (r =- 0 .9110 ,P <0 .0 1) ,而MDA则为正相关 (r =0 .92 0 6 ,P<0 .0 1)。且MDA及SOD的变化与再次受孕成功可能有关。结论 :自然流产的发生与子宫内膜局部氧化、抗氧化平衡失调有密切关系。Objective:To study the relationship of spontaneous abortion to malondialdehyde(MDA),superoxide dismutase(SOD) in sera and endomertrium.Methods:The level of MDA,SOD,CuZn-SOD were measured in sera and endometrium tissues respectively in total 60 women(20 women who had undorgone spontaneous abortion,20 women of normal early pregnancy group and 20 women of normal non-pregnancy group).Results:(1)MDA:In sera,there was no statistical difference between spontaneious and two control groups(>0.05),but in endometrium tissues,the mean level were increased in spontaneous abortion group compared with two normal groups(P<0.01).(2)In sera and endometrium tissues,the level of SOD in cases of spontaneous abortion were markedly lower than those two normal control groups(P<0.01).(3)The level of CuZn-SOD in sera and endometrium tissues were significantly increased in spontaneous abortion group than that in two control groups.(4) In endometrium tissue,significant negative correlative were found between activity of SOD and abortion frequency(r=-0.9110,P<0.01).But to MDA,it is opposite(r=0.9206,P<0.01).The changes of MDA and SOD may be associated with the next successful pregnency.Conclusions:Spontaneous abortion may be associated with the imbalance of oxidase and antioxidase in endometrium tissues.

关 键 词：流产 子宫内膜 丙二醛 超氧化物歧化酶 

分 类 号：R714.21[医药卫生—妇产科学]