通关胶囊对离体人增生前列腺α_1-AR的拮抗作用  

Inhibitory Effect of TGJN on α_1-Adrenoceptor of Human Hypertrophic Prostate in vitro

作　　者：张蜀武[1] 常德贵[1] 王久源[1] 郭凯[1] 邵继春[1] 

机构地区：[1]成都中医药大学附属医院男科,四川成都610072

出　　处：《中华男科学杂志》2001年第2期136-137,140,共2页National Journal of Andrology

基　　金：四川省教委课题!(No:97114 )

摘　　要：目的 :探讨中药通关胶囊治疗前列腺增生 (BPH)的机理。　方法 :运用放射配体结合实验观察通关胶囊对离体人增生前列腺细胞膜α1肾上腺素受体 (α1 AR)的抑制作用。　结果 :通关胶囊对人增生前列腺平滑肌细胞α1 AR与12 5IBE的结合具有竞争抑制作用 ,且呈量效关系 ,其中对中叶增生组织平滑肌细胞α1 AR亲和性最大 [Ki值(2 0 0 .3± 19.83)mg/L]。　结论 :通关胶囊对离体人前列腺细胞膜α1Objectives: To evaluate the mechanism of using TGJN(a kind of extract of Chinese herb medicine)to treat BPH. Methods: The radioligand binding assays were used to observe the inhibiting effect from TGJN to the α 1 AR in human smooth muscle cells of hyperplastic prostate. Results: TGJN can inhibit the binding of α 1 AR with 125 I BE through binding with α 1 AR.The inhibition was related to the concentration of TGJN and the inhibition was the biggest in middle lobe of human hyperplastic prostate[The Ki was (200.3±19.83)mg/L]. Conclusions: TGJN can inhibit the α 1 AR in human smooth muscle cells of hyperplastic prostate.

关 键 词：中药 通关胶囊 前列腺增生 Α1肾上腺素受体 拮抗作用 

分 类 号：R285.5[医药卫生—中药学]