^(99m)Tc-MDP在女性全身骨骼分布随年龄相关改变初探  

Approach of age－related changes of whole body bone distribution using ^(99m)Tc－MDP bone scintigraphy in women

作　　者：张凯军[1] 张永学[1] 安锐[1] 高再荣[1] 童安利[1] 

机构地区：[1]同济医科大学附属协和医院,湖北武汉430022

出　　处：《中国临床医学影像杂志》2001年第2期120-122,共3页Journal of China Clinic Medical Imaging

摘　　要：目的：了解女性全身及局部骨质代谢特点，初步探讨其随年龄变化的一些规律，对骨质转换或丢失的机理进行初步研究，为临床治疗骨质丢失性疾病提供理论基础。方法：用法国Soph公司SPECT标准程序进行全身骨显像，显像剂为^(99m)Tc－Methane－diphosphonate(^(99m)Tc－MDP)，注射剂量为925MBq。通过设置感兴趣区(ROI)来评价全身骨的代谢，并与反映骨质代谢的指标进行比较。结果：在女性，全身骨^(99m)Tc－MDP的摄取率随着年龄的增长而增加；并且随着年龄的增加，颅骨和双下肢摄取率增加，而胸廓却减少；同时在男性没有观察到此种变化趋势。在女性，全身骨、颅骨及双下肢的摄取率的增加与血液中的碱性磷酸酶(ALP)存在一定的正相关，此外，颅骨的摄取率与尿羟脯氨酸/肌酐的比值(HOP/Cr)也存在一定的正相关；而胸廓的摄取率减少与ALP呈一定的负相关。结论：研究结果表明，在女性，骨的更新和局部骨的代谢改变与年龄有关。这些改变在骨显像时也能观察到，它可能是进行性骨丢失的征象，也反映了局部骨质代谢变化。Objective:To study metabolic features of age－related changes of whole－body or regional bone in women,we attempted to obtain the skeletal metabolic regulation of age－related changes and to investigate the mechanism of skeletal turnover or loss in order to provide the theoretical foundation of suitable treatment for it.Methods:The whole－body skeletal uptake(WBSU) and whole－body skeletal tracer distribution pattern were studied or quantified by setting regions of interest(ROI) on selected regions using ^(99m)Tc－methane－diphosphonate (^(99m)Tc－MDP,injected doses:925MBq) bone scan and correlated with biochemical bone metabolic markers reflecting total skeletal metabolism in blood and urine.Bone scans were performed using a standard protocol of SPECT (Sopha,France). Result:In women,uptake of ^(99m)Tc－MDP in the whole－body,head and legs regions increases with age,but that of thoracic region reduces with age.The increasing uptake of head and legs has a medium correlation with the levels of alkaline phosphatase(ALP,in the meantime,uptake of head has a medium correlation with hydroxy－proline/creatinine,HOP/Cr),but reduction of uptake of thorax has a medium correlation with ALP.Conclusions:These results show that bone turnover and regional bone metabolism relate with women's age.The aged－related changes can be observed in bone scan;it may be a sign of progressive bone loss and also reflect changes of regional bone metabolism.

关 键 词：99米锝美罗酸盐 放射性核素显像 骨骼 

分 类 号：R681[医药卫生—骨科学] R816.8[医药卫生—外科学]