2型糖尿病患者血清胰岛素受体抗体的检测  

The detection of anti-insulin receptor antibodies in serum of diabetes mellitus

作　　者：朱宁[1] 王嘉仪[1] 王维兆[1] 汤新之[1] 

机构地区：[1]天津医科大学生化教研室,300070

出　　处：《天津医科大学学报》2001年第1期9-10,共2页Journal of Tianjin Medical University

基　　金：天津市教委科学基金资助课题 !(课题号96409)

摘　　要：目的 :建立血清胰岛素受体抗体的检测方法 ,探讨胰岛素受体抗体与胰岛素抵抗的关系。方法 :放射免疫分析法测定去胰岛素血清对125I -胰岛素与胰岛素受体特异结合的影响。结果 :批内变异系数为4.9 % ,批间变异系数为12.5 %。26例2型糖尿病患者中有3例呈胰岛素受体抗体阳性。结论 :胰岛素受体抗体与胰岛素抵抗密切相关。Objective:To establish a method of detecting anti-insulin receptor antibodies of serum and study the relationship between anti-insulin receptor antibody and insulin resistance. Methods: The specfic 125I-insulin binding to insulin receptor with serum was measured by radioimmunoassay. Results: CV (coefficient of variation) within the batch was 4.9%. CV between the batches was 12.5%. There were anti-insulin receptor antibodies in 3 of 26 diabetes mellitus. Conclusion: Anti-insulin receptor antibodies could have resulted in insulin resistance.

关 键 词：胰岛素体抗体 放射免疫分析法 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]