胎盘部位结节  

Placenta site nodules and plaques

作　　者：姚青[1] 张建民[1] 郭庆明[1] 蒋静娟[1] 

机构地区：[1]东南大学附属中大医院病理科,南京210009

出　　处：《江苏医药》2001年第5期333-334,I001,共3页Jiangsu Medical Journal

摘　　要：目的　报告 6例胎盘部位结节的临床及病理学特征 ,进一步认识到该病变是一种残留的胎盘部位组织 ,与当前妊娠缺乏联系。方法　在刮宫及子宫切除标本常规HE切片的光镜观察中偶然发现。其中 2例分别做角蛋白、胎盘促乳素及绒毛膜促性腺激素三项免疫组化标记。结果　光镜下为界清的广泛玻璃样变的结节 ,病变细胞为中间滋养层细胞 ,其免疫组化标记角蛋白为弥漫强阳性 ,胎盘促乳素少数细胞强阳性。结论　胎盘部位结节是良性病变 ,须与正常宫内妊娠。Objective The clinical and pathological features of 6 cases of placental site nodule/plaques(PSN/P) are described.The lesions represented a remnant of placental site tissue,which had tight association with ancient pregnancy.Methods They were incidental finding in curettage or hysterectomy specimens and microscopic findings only with HE stained.Two of the 6 cases were stained immunohistochemically for cytokeration AE1/AE3(CKAE1/AE3),human placental lactogen(hPL),and human chorionic gonadotropin (hCG).Results Microscopic examination disclosed mostly well circumscribed and extensively hyalinized nodules with typically intermediate trophoblast cells (Its),in which staining for CKAE1/AE3 was diffusedly positive and hPL was focally positive.Conclusion PSN/P is benign in nature and it must be differentiated from pregnancy in the uterus,the placental site trophoblastic tumor and a kind of squamous cell carcinoma of cervix.

关 键 词：胎盘部位结节 中间滋养层细胞 病理学 残留胎盘部位组织 诊断 

分 类 号：R714.43[医药卫生—妇产科学] R714.56[医药卫生—临床医学]