微量元素与细胞外基质  

TRACE ELEMENTS AND EXTRACELLULAR MATRIX

作　　者：缪宓[1] 秦泽莲[2] 牛星焘[2] 

机构地区：[1]北京安贞医院激光整形科 [2]北京大学第三医院成形外科

出　　处：《中国修复重建外科杂志》2001年第3期188-190,共3页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　论述微量元素对细胞外基质代谢的影响 ,探讨创伤愈合的生理和相关病理机制。方法以基础研究结合相关临床资料 ,分析微量元素与细胞外基质代谢的关系 ,探讨创伤修复机制。结果　在创伤愈合过程中 ,微量元素通过参与酶的构成与激活、构成体内重要的载体及蛋白质成份、参与激素和维生素的合成以及调控自由基水平等功能 ,广泛参与到胶原蛋白和其它细胞外基质的合成、分解、沉积与重建过程中。结论　微量元素对细胞外基质的代谢起着一定的调控作用 。Objective To investigate the effects of trace elements on the metabolism of extracellular matrix and explore the physiological and pathological mechanism of trauma. Methods Based on the experimental and clinical data, it was studied that the action of trace elements in the metabolism of extracellular matrix in trauma repairing. Results During wound healing, the trace elements were the components of many kinds of enzymes, carriers and proteins. They took part in the synthesis of hormones and vitamins as well as the transmission of information system. They activated many different kinds of enzymes and regulate the levels of free radicals. The trace elements had the complicated effects on the synthesis, decompose, deposition and reconstruction of collagen and other extracellular matrix. Conclusion The trace elements play an important role in regulating the metabolism of extracellular matrix.

关 键 词：微量元素 细胞外基质 创伤愈合 胶原 合成 

分 类 号：R641[医药卫生—外科学]