双黄升白冲剂对化疗引起骨髓抑制的临床研究及小鼠骨髓超微结构的观察  

Clinical and Experimental Study on Effect of Shuanghuang Shengbai Granule on Myelosuppression Induced by Chemotherapy and Ultrastructure Observation of Bone Marrow in Mice

作　　者：徐振晔[1] 朱晏伟[1] 周卫东[1] 张晖[1] 鞠艳芳[1] 赵丽红[1] 邓海滨[1] 吴继[1] 沈德义[2] 张蕙心[3] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]河北省肿瘤医院 [3]上海第二医科大学电镜室

出　　处：《中国中西医结合杂志》2001年第5期328-331,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市科委科研基金资助课题! (No .9640 1 90 37)

摘　　要：目的 :观察中药双黄升白冲剂对肿瘤化疗患者的升白疗效及对小鼠骨髓造血微环境的作用。方法 :选择主要为复治的非小细胞肺癌及乳腺癌、胃癌、肠癌患者 ,随机分为 4组。治疗 1组 ( 2 8例 )为化疗同时服用双黄升白冲剂 ;治疗 2组 ( 2 7例 )为WBC <4× 10 9/L始用双黄升白冲剂 ;对照 1组 ( 33例 )为化疗同时服用茜草双酯 ;对照 2组 ( 2 4例 )为WBC <4× 10 9/L始用茜草双酯。并做实验研究电镜观察小鼠骨髓超微结构。结果 :升白疗效总有效率治疗 1组为 75 0 0 % ,治疗 2组为 88 89% ;对照 1组为 54 55% ,对照 2组为 58 33%。治疗组与对照组比较差异有显著性 (P <0 0 1)。双黄升白冲剂对小鼠骨髓有良好的保护、改善造血微环境的作用。结论Objective: To observe the leukocyte increasing effects of Shuanghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy (CT) and its function on bone marrow hematopoietic microenvironment in mice. Methods: Patients of non small cell lung cancer and breast, gastric or intestinal cancer, who were retreated with CT, were enrolled and divided into 4 groups randomly. The 28 cases in the treated group 1 received SHSBG and CT simultaneously. The 27 cases in the treated group 2 also received firstly CT, and SHSBG started when WBC count lowered to less than 4×10 9/L after CT. The control group 1 and 2 (n=33 and n=24) was treated by the method similar to that applied to the treated group 1 and 2 respectively but with Rubidate instead of SHSBG. Experimental study of observing bone marrow ultrastructure in mice was also conducted with electron microscopy. Results: The total leukocyte increasing effective rate occurred in the treated group 1 was 75.00%, that in the treated group 2 was 88.89%, in the control group 1 was 54.55% and in the control group 2 was 58.33%. There was significant difference between the treated groups and the control groups (P<0 01). Experimental study showed that SHSBG has good bone marrow hematopoietic microenvironment protecting and improving effect in mice. Conclusion: SHSBG has obvious protecting and treating effect on CT caused bone marrow suppression in tumor patients.

关 键 词：双黄升白冲剂 化疗 骨髓抑制 升白细胞 骨髓 超微结构 临床研究 

分 类 号：R285.6[医药卫生—中药学]