中药狼疮定对系统性红斑狼疮患者血清可溶性白细胞介素-2受体和新喋呤水平的影响  

Effect of Langchuangding on Serum Soluble Interleukin-2 Receptor and Neopterin Level in Patients of Systemic Lupus Erythematosus

作　　者：温成平 范永升 李学铭 

机构地区：[1]浙江中医学院中医临床研究所,杭州310053

出　　处：《中国中西医结合杂志》2001年第5期339-341,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然基金资助项目的部分内容! (No .39870 92 1 )

摘　　要：目的 :观察中药狼疮定对系统性红斑狼疮 (SLE)患者血清可溶性白细胞介素 2受体 (sIL 2R)和新喋呤 (neopterin)水平的影响 ,探讨其治疗SLE可能的作用机理。方法 :筛选 4 5例SLE患者 ,随机分成两组 ,激素并用狼疮定组 2 5例 ,单用激素组 2 0例 ,运用ELISA双抗夹心法等检测用药前后sIL 2R、neopterin水平。结果 :SLE患者sIL 2R、neopterin水平明显高于健康人 ,活动期高于缓解期 ,且neopterin水平与血沉水平呈正相关性 (r =0 86,P <0 0 1) ;治疗后激素并用狼疮定组sIL 2R、neopterin水平明显低于单用激素组 (P <0 0 5)。结论 :狼疮定能有效降低SLE患者sIL 2R、neopterin水平 ,利于调节细胞免疫功能 ,使紊乱的免疫内环境趋于平衡。Objective: In order to explore the therapeutic mechanism of Langchuangding (LCD) in treating systemic lupus erythematosus (SLE) by observation of its effect on serum soluble interleukin 2 receptor (sIL 2R) and neopterin level in SLE patients. Methods: Forty five patients of SLE were randomly divided into two groups, the 25 cases in the treated group were treated with LCD plus glucocorticoid (GCC) and the 20 cases in the control group were treated with GCC alone. The levels of sIL 2R and neopterin were observed before and after treatment by double antibody sandwich ELISA. Results: SLE patient showed higher levels of sIL 2R and neopterin than normal, and being higher in active stage than in remission stage. The level of neopterin was positively correlated with erythrocyte sedimentation rate (ESR) (r=0.86, P<0 01). After treatment, the levels of sIL 2R and neopterin were lowered significantly in the treated group than those in the control group (P<0 05). Conclusion: LCD could effectively reduce the serum levels of sIL 2R and neopterin in SLE patients, which would be beneficial to cellular immune functional regulation and induce the disturbed internal environment of immunity to homeostasis.

关 键 词：系统性红斑狼疮 可溶性白细胞介素-2受体 新喋呤 狼疮定 中医药疗法 治疗 

分 类 号：R259[医药卫生—中西医结合]