^(241)镅跟骨骨密度测定在骨质疏松症中的初步应用——与腰椎骨密度测定的对比研究  

Preliminary application of 241-Americium calcaneus bone mineral density measurement in osteoporosis ——comparison with double X-ray densitometry of the lumber spine

作　　者：管梁[1] 朱承谟[1] 李培勇[1] 王辉[1] 濮鸣芳[1] 仇季高[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海200025

出　　处：《核技术》2001年第5期345-349,共5页Nuclear Techniques

摘　　要：为评价跟骨骨密度测定在骨质疏松症中的初步临床应用及与腰椎测定结果的相关性 ,用国产华科 (HK - 1型 ) 2 4 1镅骨密度仪测定了 140例跟骨骨密度 (BMD)。其中正常人组 54例 ,骨质疏松确诊组 4 5例 ,骨质疏松可疑组 2 5例和其他非骨质疏松组 16例。其中 4 3例与美国Luner公司的Expert-XL图像骨密度仪腰椎测定结果进行对照。结果表明 ,正常人组跟骨BMD为 ( 4 0 9.8±79.4 )mg cm2 ,随年龄的增长BMD逐渐降低 ;骨质疏松确诊组、骨质疏松可疑组和其他非骨质疏松组的BMD分别为 ( 2 30 .3± 62 .3)、( 395.7± 57.4 )、( 363.3± 51.9)mg cm2 。在骨质疏松组确诊组中 ,其BMD值明显低于正常人组 ,也低于骨质疏松可疑组和其他组 ,且 2 6例 ( 57.78% )伴有骨折 ,与骨质疏松的临床诊断符合。在骨质疏松可疑组和其他组的BMD ,与正常人比较无明显差异。 4例跟骨骨密度重复性检测误差均小于 1.2 %。 4 3例腰椎与跟骨的BMD测定的相关性r为 0 .682 4 ,两组间与正常青年人对照 ( % ,T值 )r分别为 0 .6863和 0 .6755;两组间与同年龄组人对照 ( % ,Z值 )r值分别为 0 .4 614,0 .50 0 9。上述结果表明 ,国产2 4 1镅跟骨骨密度仪对诊断骨质疏松症具有较高的临床应用价值。腰椎与跟骨的BMD测定值以及两者间正常青年人对照 ( %Bone mineral density (BMD) of calcaneus in 54 normals, 45 Osteoporosis, 25 suspected osteoporosis and 16 other non-osteoporosis patients, a total of 140 cases were measured by HUAKE (HK-1) 241-Americium BMD absorpmetry, among them 43 were compared with that of lumber spine (L2—L4) measured by Lunar Corporation's Expert-XL absorpmeter. BMD of normal group of calcaneus was (409.8±79.4)mg/cm 2. The BMD were decreased slowly with the increased age. The BMD of osteoporosis, suspected osteoporosis and non-osteoporosis group were 230.3±62.3, 395.7±57.4 and 363.3±51.9mg/cm 2 respectively. The BMD of osteoporosis group was much lower than that of normal group, and also lower than that of the other two groups, among 26 patients (57.78%) had bone fracture, all was in accordance with the clinical diagnosis of osteoporosis. The BMD of suspected ospteoporosis and non-osteoporosis had no significant difference with normal group. The coefficient variation (CV) of BMD in repeated measurement in calcaneus of 4 pariticipants was less than 1.2%. The correlative coefficient ( r ) between BMD of calcaneus and lumber spine (L2—L4) group was 0.6824. The correlative coefficient of normal young adult-matched percentage and T value in 2 groups were 0.6863 and 0.6755 respectively, whereas aged-matched percentage, Z value were 0.4614 and 0.5009 respectively. In conclusion 241-Americium calcaneus BMD absorpmetry has the advantage of low price, easy to operate, reliable and valuable in diagnosis osteoporosis. The correlations of calcaneus and lumber spine BMD, normal young adult-matched percentagy and T value were rather good.

关 键 词：骨密度 骨质疏松 跟骨 诊断 测定 双能X线骨密度仪 相关分析 腰锥 镅241 放射性同位素 

分 类 号：R817.48[医药卫生—影像医学与核医学]