用^(125)I-β-CIT与^(125)I-IBZM体内放射自显影研究MPTP致帕金森病小鼠中枢多巴胺转运蛋白与受体变化  

Density changes in striatal dopamine transporters and D_2 receptors in MPTP treated mouse model

作　　者：孙文善[1] 刘振国[1] 沈鸣华[2] 李培勇[1] 朱承谟[1] 陈生弟[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海200025 [2]复旦大学药学院,上海200032

出　　处：《核技术》2001年第5期413-416,共4页Nuclear Techniques

摘　　要：应用12 5I- β -CIT和12 5I-IBZM体内放射自显影技术研究了MPTP致帕金森病小鼠中枢多巴胺转运蛋白 (DAT)与多巴胺D2 受体 (D2 R)变化。结果表明 :对于给予MPTP ( 30mg kg·d)日数分别为 1、3、5、7d的小鼠 ,用药早期 ,DAT密度即表现为降低 ,而D2 R密度在早期未有显著改变。随着日数增加 ,D2 R密度表现为升高 ,受体呈超敏状态。提示联合应用DAT与D2 R显像剂同时进行SPECT显像 ,有利于临床PD病诊断与鉴别诊断以及评估黑质 -纹状体DA神经元的变性程度。To observe the density changes of the dopamine transporters (DAT) and receptors in MPTP treated mouse model. Mice ( n =30) were given i.v. injections of 30mg/kg MPTP for 1, 3, 5, 7 days respectively, and in vivo autoradiographic experiments were performed in the striatum using β-CIT for DAT, and IBZM for D 2R. Results showed that a significant decrease of 125 I-β-CIT binding was observed in the early phase, while no dramatic change occurred in 125 I-IBZM binding, but D 2R showed supersensitivity in the later stage. Thus combined imaging of DAT and D 2R may provide a valuable information for clinical and differential diagnosis of PD and assessment of the magnitude of degeneration of nigrastriatum.

关 键 词：Β-CIT IBZM 多巴胺转运蛋白 多巴胺D2受体 放射自显影 碘125标记物 显像剂 帕金森病 显像剂 诊断 

分 类 号：R817.41[医药卫生—影像医学与核医学] R742.5[医药卫生—放射医学]