夏天无总碱对血小板内cAMP、cGMP含量的影响  

Effects of Corydalis amabilis Migo total alkaloids on platelet cyclic AMP and cyclic QMP

作　　者：刘忞 冯高闳[1] 蔡锡麟[1] 

机构地区：[1]江西医学院

出　　处：《核技术》1990年第1期61-63,共3页Nuclear Techniques

摘　　要：夏天无总碱(COAMTA)系从伏生紫堇之块茎中分离出的有效成分。动物实验表明,COAMTA具有明显抑制血小板聚集、抑制血栓形成等作用。本文观察了COAMTA对家兔血小板内cAMP和cGMP含量的影响。结果0.08—0.16mg/ml PRP的COAMTA可明显提高血小板内cAMP含量;剂量为0.16mg/ml PRP还可使cGMP含量升高,但cAMP/cGMP的比值增加更为明显,提示COAMTA主要是通过影响cAMP含量而发挥抑制血小板功能的作用。Corydalis amabilis Migo total alkaloids (COAMTA), isolated from the root of Co-rydalis decumbens (Thunb) Pers, possessed inhibitory action on ADP-induced blood platelet aggregation and the formation of thrombus in animal experiments. Its effects on the platelet cyclic AMP and cyclic GMP in incubated rabbit platelet were measured by radioimmunoassay.cAMP was significantly elevated when COAMTA was given 0.08-0.16mg/ml PRP. In concentration up to 0,16 mg/ml PRP, COAMTA elevated cGMP, but the ratio value of cAMP/cGMP was much higher than that of control group. These results suggest that the anti-platelet activity of COAMTA were mediated through elevation of cAMP levels.

关 键 词：聚集 夏天无 环磷酸腺苷 环磷酸鸟苷 高血压 植物药 血小板 抑制作用 脑血管疾病 治疗 总碱 

分 类 号：R285[医药卫生—中药学] R277.73[医药卫生—中医学]