C-反应蛋白与急性冠状动脉综合征关系的临床研究  

The clinical investigation of the relationship between C-reactive protein and acuate coronary artery syndrome

作　　者：谭文锋[1,2] 张荫川[1,2] 余泽洪[1,2] 黄振文[1,2] 汤立军[1,2] 古国荣[1,2] 陈林祥[1,2] 

机构地区：[1]广东省江门市人民医院心内科 [2]江门市心血管病研究所

出　　处：《岭南心血管病杂志》2001年第2期118-119,共2页South China Journal of Cardiovascular Diseases

摘　　要：目的　通过比较急性冠状动脉综合征 (ACS)患者与健康正常人血浆C 反应蛋白 (CRP)浓度的变化 ,探讨炎症反应在ACS发病所起的作用。方法　对 2 3例急性心肌梗死 (AMI)和 36例不稳定型心绞痛 (UAP)患者在急性发病时测定血浆CRP浓度 ,并行 2 4h动态心电图检查记录缺血总负荷。结果　AMI和UAP患者血浆CRP浓度明显比健康正常人高 (P <0 0 1) ,缺血总负荷大于 10 0 0mm·min与小于 10 0 0mm·minACS患者中血浆CRP浓度无显著性差异 (P >0 0 5 )。结论　CRP与冠状动脉 (冠脉 )斑块活动有关 ,与心肌缺血的程度无关 ,炎症反应是导致ACS发生的原因之一。Objective To compare the concentrations of plasma C reactive protein(CRP) in patients with acute coronary artery syndrome(ACS) and healthy persons, evaluating the effect of inflammatory reaction in ACS. Methods The concentrations of plasm CRP were measured in twenty three of patients with acute myocardial infarction(AMI) and thirty six of patients with unstable angina(UAP) who were on acute phase, and total ischemic burden was observed during Holter monitoring in patient.Results The concentrations of plasm CRP in patients with AMI and UAP were significantly higher than healthy persons ( P <0 01), but there were no significance between the patients with ACS whose total ischemic burden was more than 1 000 mm·min and less than 1 000 mm·min( P >0 05).Conclusion Elevated levels of CRP are associated with active coronary plaques, aren't associated with degrees of myocardial ischemia Inflammatory reaction is one of the reasons to occur ACS.

关 键 词：C-反应蛋白 斑块 缺血 急性冠状动脉综合征 冠心病 

分 类 号：R541.402[医药卫生—心血管疾病]