亚硒酸钠对小鼠的胚胎毒性  

EMBRYOTOXICITY OF SODIUM SELENITE IN MOUSE

作　　者：赵红刚[1] 陈贤均[2] 甘亚平[1] 

机构地区：[1]咸宁医学院病理学教研室 [2]咸宁医学院生物学教研室,湖北咸宁437100

出　　处：《癌变．畸变．突变》2001年第2期85-88,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的 :探讨亚硒酸钠对小鼠的胚胎毒性、致畸作用、致畸剂量和致畸特性。方法 :采用小鼠整体致畸试验 ,测量胎鼠的体重、体长、尾长 ,统计胎鼠死亡率和吸收率 ,观察内、外部畸形 ,并对胎鼠的上枕骨、胸骨、指骨等骨骼的骨化点的骨化程度进行分级与计数 ;运用方差分析、χ2 检验及秩和检验等方法对所得数据进行统计分析。结果 :低剂量 (0 .6mg/kg·bw)为无作用剂量 ,中 (3mg/kg·bw)、高 (15mg/kg·bw)剂量组的枕骨、指骨及胸骨有明显骨化不良和发育迟滞现象 ,与正常组比较 ,具有显著性差异 (P <0 .0 5～ 0 .0 0 5 )。结论 :亚硒酸钠有胚胎毒性作用 ,但未发现引起内脏及外部畸形。Purpose: To probe into the embryotoxicity, the teratogenic effect of sodium selenite as well as its \{teratogenic\} dosage and characteristics were studied. Methods: The body weight, body length and tail length of \{fetuses\} were measured, the death rate of fetuses and the rate of absorbed embryos were counted, the external \{appearances\} and internal organ malformations were observed, ossificated gradation of supraoccipital bone, ossification centers in caudal, forelimb and hindlimb, as well as degree of ossification agenesis in sternebrae were graded and counted. Statistics analysis was made with analysis of variance, chi square and rank sum test. \{Results:\} The low dosage (0.6 mg/kg·bw) was ineffective. In middle (3 mg/kg·bw) and high (15 mg/kg·bw) dosage groups, there were agenesia of supraoccipital bone, sternebrae, forelimb and hindlimb in fetuses and the differences were significant (P<0.05～0.005) comparing the two groups with the control group. Conclusion: Sodium selenite possesses embryotoxicity, its toxicity dosage for mice is 3 mg/kg·bw and above; it causes only mouse embryo or fetus ossification agenesis and development retardation.

关 键 词：亚硒酸钠 致畸性 胚胎毒性 

分 类 号：R992[医药卫生—毒理学]