注射用阿奇霉素治疗细菌性感染临床观察  

Injective azithromycin in treatment of bacterial infections

作　　者：陈余清[1] 陈卫东[2] 熊肇军[1] 张燕[2] 

机构地区：[1]蚌埠医学院附属医院呼吸科,安徽蚌埠233004 [2]蚌埠医学院附属医院肾病科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2001年第3期198-199,共2页Journal of Bengbu Medical College

摘　　要：目的 :评价国产注射用阿奇霉素治疗细菌性感染的临床疗效和安全性。方法 :采用随机对照方法 ,将 43例下呼吸道感染和 33例泌尿道感染分验证组和对照组。 43例验证组给予注射用阿奇霉素 0 .2 5 g静脉滴注 ,每天 1次 ;33例对照组给予注射用头孢呋辛 1.5g静脉滴注 ,每天 2次 ,两组疗程均为 5天。结果 :验证组有效率为 83.7% ,细菌清除率为 72 .5 % ,药物敏感率为 80 .8% ;对照组有效率为 81.8% ,细菌清除率为 77.4% ,药物敏感率为 82 .2 % ,两组差异均无显著性 (P >0 .0 5 )。两组不良反应轻微。结论 :注射用阿奇霉素是一种有效。Objective:To evaluate the efficacy and safety of injectio azithromycin made in China.Methods:Forty three cases of lower respiratory infections and 33 cases of urinary tract infections were divided into test group and control group.Patients in the test group were injected azithromycin 0.25 g per day for 5 days,in the control group were injected cefuroxime 3.0 g per day for 5 days.Results:The effective rate,bacterial eradication rate and sensitive rate in the test group were 83.7%,72.5% and 80.8% respectively,while in the control group,they were 81.8%,77.4% and 82.2% respectively.There was no significant difference between the two groups( P > 0.05 ),and the side effects were slight.Conclusions:Injectio azithromycin is effective and safe in treatment of bacterial infection diseases.

关 键 词：抗生素类 大环内酯 阿奇霉素 临床试验 细菌性感染 

分 类 号：R515[医药卫生—内科学] R978.15[医药卫生—临床医学]