眼镜蛇毒抗补体因子的研究  

Study on cobra venom factor

作　　者：叶春玲[1] 任先达[1] 吕艳青[1] 叶开和[1] 

机构地区：[1]暨南大学医学院药理学教研室,广东广州510632

出　　处：《中国病理生理杂志》2001年第5期473-476,480,共5页Chinese Journal of Pathophysiology

基　　金：广东省自然科学基金!资助 (No .970 47)

摘　　要：Cobra venom factor (CVF), separated from the cobra venoms, is an acidic glucoproteins with anticomplementory activity The combination of CVF with factor B in the blood produces a stable C3 and C5 converterase resulting in complement depletion by activating complement continually. There are many studies on it, such as inflammation, autoimmune disease, xenotransplantation, anti-tumor, etc. CVF is also an important tool drug for the study of complement role in the pathophysiological development of diseases.Cobra venom factor (CVF), separated from the cobra venoms, is an acidic glucoproteins with anticomplementory activity The combination of CVF with factor B in the blood produces a stable C3 and C5 converterase resulting in complement depletion by activating complement continually. There are many studies on it, such as inflammation, autoimmune disease, xenotransplantation, anti-tumor, etc. CVF is also an important tool drug for the study of complement role in the pathophysiological development of diseases.

关 键 词：眼镜蛇毒液类 补体 补体激活 CVF 眼镜蛇毒因子 

分 类 号：R996.3[医药卫生—毒理学]