E838等5种辐射防护药对放烧复合伤防治作用的实验观察  

Experimental study on preventive and therapeutic effects of 5 radioprotectants on combined radiation-burn injured mice

作　　者：郭朝华[1] 孔佩艳 邹仲敏[1] 周燕虹[1] 周进明[1] 张勇[3] 史春梦[1] 冉新泽[1] 罗成基[1] 

机构地区：[1]第三军医大学预防医学系防原医学教研室,全军复合伤研究所,重庆400038 [2]第三军医大学附属新桥医院血液内科,重庆400037 [3]第三军医大学附属西南医院血液内科,重庆400038

出　　处：《第三军医大学学报》2001年第5期544-546,共3页Journal of Third Military Medical University

基　　金：总后卫生部科研基金资助项目

摘　　要：目的　比较研究E838、WR 2 72 1、茜草、盐酸胱胺和炔雌醇等 5种辐射防护药对放射损伤和放烧复合伤的防治作用及其相互间的协同作用。方法　采用小鼠腹腔注射、灌胃的方法在致伤前 /或和致伤后按常用量给药 ,观察 30d存活率、死亡动物平均存活日和保护系数K的差异。结果　①致伤前预防给药 ,5种药物均明显提高了放射损伤和放烧复合伤的存活率 ,并延长了死亡动物的平均存活日 ,其中以E838和WR 2 72 1效果最佳 ;②致伤后给药则仅E838和茜草显示了治疗效果 ;③联合用药实验显示所研究的 5种配伍用药方式均有较好的防治效果 ,但以WR 2 72 1 +E838治效果最好。结论　E838和WR 2 72 1与其它辐射防护药相比具有较理想的辐射防护作用 ,且E838还有一定的治疗作用 。Objective To compare the irradiation protective and inter synergestic effects of E838,WR 2721, Rubia cordifolia , cystamine hydrochloride and ethinyl estradiol on radiation and combined radiation burn injury. Methods Above mentioned drugs were given to the mice intraperitoneally, or intragastrcally, then, the mortality and the average survival d for 30 d were observed before and after the administration of the drugs. Results ①When drugs were before injury , the survival rate and the average survival d of the radiation and combined radiation burn injured mice were increased obviously with the best effect in E838 and WR 2721. ②When drugs were given after injury, E838 and R. cordifolia also kept the effect. ③Combined appling WR 2721(pre) and E838(post)displayed a significant synergistic reaction. Conclusion E838 and WR 2721 are more effective than the others in the prevention of radiation.

关 键 词：E838 WR-2721 放烧复合伤 辐射防护 

分 类 号：R644[医药卫生—外科学] R818[医药卫生—临床医学]