左旋精氨酸治疗高原肺水肿疗效观察  

THE CURATIVE EFFECTS OF L-ARGININE ON HIGH ALTITUDE PULMONARY EDEMA

作　　者：张西洲[1] 马勇[1] 王伟[1] 王引虎[1] 崔建华[1] 哈振德[1] 朱永安[1] 叶城[1] 解放军第 

机构地区：[1]解放军第18医院

出　　处：《解放军医学杂志》2001年第5期378-379,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：在海拔 370 0m高度采用静脉滴注左旋精氨酸 (L Arg)治疗高原肺水肿患者 10例 ,并与吸入一氧化氮 (NO)混合气体治疗的 11例和常规治疗的 2 4例作对照。NO组肺部湿音和X线阴影消失时间较精氨酸组缩短 (P <0 .0 1) ,但病程日差异无显著性意义 (P >0 .0 5 ) ;常规组肺部湿音和X线阴影消失时间及病程日较NO组延长 (P <0 .0 5或P <0 .0 1) ;精氨酸组肺部X线阴影消失时间和病程日较常规组缩短 (P <0 .0 1)。作者认为 ,静脉滴注L Arg治疗高原肺水肿经济简便、无毒性 ,便于基层推广应用。In order to study the curative effects of L arginine (L Arg) on high altitude pulmonary edema (HAPE),we had treated 10 patients with HAPE by intravenous L Arg at 3700m, and the result was compared with 11 patients who inhaled low concentration nitric oxide (NO) and 24 subjects with routine treatment.The findings were as follows:compared with the routine group, inhaling NO or intravenous L Arg could hasten the disappearance of moist rales and X ray shadow, and shorten the illness time( P <0.05 or P <0.01); in the NO group rales disappeared earlier than those of the L Arg group ( P <0.01), but there was no difference in duration of the illness( P >0.05). It suggested that intravenous L Arg is a handy way to treat HAPE, and there is no toxicity. It is worthy of further trial.

关 键 词：高原肺水肿 左旋精氨酸 一氧化氮 清脉滴注 

分 类 号：R541.63[医药卫生—心血管疾病] R594.3[医药卫生—内科学]