中国人混合型高脂血症患者脂蛋白脂酶常见基因变异的筛查  

Common genetic variants of lipoprotein lipase in Chinese combined hyperlipidemia

作　　者：赵迎社[1] 周羽并[1] 林春兰[1] 吴美玉[1] 严玉霞[1] 杨中汉[1] 周天鸿[2] 

机构地区：[1]暨南大学医学院生化教研室,广州510632 [2]暨南大学医学院生命科学技术学院,广州510632

出　　处：《广东医学》2001年第5期381-382,共2页Guangdong Medical Journal

基　　金：广东省自然科学基金!项目 (编号 990 4 67)

摘　　要：目的　研究中国人混合型高脂血症 (CHL)患者脂蛋白脂酶 (LPL)常见基因变异情况。方法　应用多聚酶链反应 (PCR)对广东地区 15 6例混合型高脂血症患者脂蛋白脂酶基因的多态性进行了研究 ,检测的LPL基因突变位点有 :-93T→G、Asp9→Asn及Asn2 91→Ser突变。结果　 15 6例混合型高脂血症患者均未检出上述突变基因。结论　在欧洲白种人存在的与混合型高脂血症相关联的LPL常见的基因变异可能与中国人混合型高脂血症无关。Objective\ To study the common gene variation of lipoprotein lipase (LPL) in Chinese combined hyperlipidemia(CHL). Methods\ DNA polymorphisms of LPL were studied by using polymerase chain reaction (PCR) in 156 combined hyperlipidemia patients from a population of Chinese Han nationality in Guangdong area. The loci studied included -93T→G, Asp9→Asn and Asn291→Ser of LPL. Results\ No positive cases were detected in any of 156 cases of combined hyperlipidemia. Conclusion\ Genetic variants of LPL in Caucasians may not be associated with combined hyperlipidmia in Chinese population.

关 键 词：混合型高脂血症 脂蛋白脂酶 基因多态性 中国人 CHL 

分 类 号：R589.2[医药卫生—内分泌]