慢性病毒性肝炎患者抗病毒治疗前后血清IL-10、IL-12水平变化及意义  

Detection of IL-10,IL-12 level in sera of patients with chronic hepatitis B before and after antiviral treatment

作　　者：李东复[1] 孟宪明[1] 王丽英[1] 太京华[1] 金珍婧[1] 

机构地区：[1]吉林大学第二医院消化内科,吉林长春130041

出　　处：《白求恩医科大学学报》2001年第3期260-261,共2页Journal of Norman Bethune University of Medical Science

摘　　要：目的 :观察慢性病毒性肝炎患者应用大剂量干扰素治疗前后白细胞介素 - 10 ( IL- 10 )、白细胞介素 - 12 ( IL - 12 )水平变化及意义。方法 :应用 EL ISA法测定应用大剂量干扰素治疗前后的乙肝病人血清 IL - 10、IL - 12水平。结果 :治疗前 IL- 10、IL - 12水平分别为 ( 35.3± 13.5) pg/ L,( 51.3± 31.5) ng/ L ,治疗后分别为 ( 18.7± 11.3) pg/ L ,( 92 .7± 61.5) ng/ L。疗程结束 ,血清 HBV- DNA与 HBe Ag阴转率为53.8% ,明显高于对照组 12 .5% ( P<0 .0 1)。结论 :应用大剂量干扰素治疗后的乙肝患者 IL - 12水平升高 ,IL - 10水平下降 ,抗病毒免疫状态增强。Objective: To observe IL 10,IL 12 level changes in sera of patients with hepatitis B treated by interferon.Methods: IL 10,IL 12 level changes were detected by ELISA in sera of patients with hepatitis B before and after treatment. Results:IL 10,IL 12 levels in sera of the patients were (35.3±13.5) pg/L,(51.3± 31.3 ) ng/L before treatment and (18.7±11.3) pg/L,(92.7±61.5) ng/L after treatment respectively. Conclusion: The IL 12 level in sera of the patients increased, IL 10 level lowered and immune states of patients were enhanced after treatment . [

关 键 词：干扰素 白细胞介素-10 白细胞介素-12 慢性病毒性肝炎 

分 类 号：R512.6[医药卫生—内科学]