硬膜外利多卡因对开胸鼠低氧血症的影响  

Effects of epidural lidocaine on hypoxemia induced by bilateral thoracotomy in rats

作　　者：潘芳[1] 郭英 王雨青 李文志[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院,150086 [2]青岛市骨伤科医院

出　　处：《黑龙江医药科学》2000年第3期28-29,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的：探讨硬膜外利多卡因对双侧开胸所致低氧血症的作用．方法：选择20只wistar大白鼠为研究对象，腹腔内注入戊巴比妥钠（35mg.kg-1）麻醉下经气管切开口插入气管导管，行机械通气．于腰3-4间隙行硬膜外腔穿刺并留置导管。结果：所有动物的潮气量（VT）及动脉血氧分压（PaO2）于双侧开胸后均明显降低（P＜0．01）．且下降的PaO2不能通过增加潮气量而改善PaO2（P＜0.05）．结论：双侧开胸后潮气量及PaO2均明显下降。硬膜外腔注入利多卡因可明显改善由双侧开胸引起的低氧血症。Objective: To investigate the effects of epidural lidocaine on hypoxemia induced by bilateral thoracotomy in rats.Method: Twenty rats were anesthetized by an intraperitoneal injection of pentobarbital sodiurn (35mg.kg-1), and intUbated through tracheotomy. All rats were ventilated with a ventiIator and epidural catheter placed through L3-4. Results: Tidal volumc(VT) and PaO2 in all rats decreased significantly after bilateral thoracotomy, and the decreased significantly after bilateral thoracotomy and the decreased PaO2 failed to change by increasing VT However. PaO2 retumed to normal with increacing VT ConcIusion: Bilateral thoracotomy induces a decreased VT and PaO2, and epidural lidocaine can improve obviously decreased PaO2 by bilateral thomeotomy.

关 键 词：双侧开胸 低氧血症 硬膜外阻滞 利多卡因 

分 类 号：R655[医药卫生—外科学] R614.4[医药卫生—临床医学]