九子参总皂甙药理研究  

Pharmacological Study of Total Glycosides Extracted from Silene Aprica

作　　者：邝荔香[1,2,3] 李涛[1,2,3] 刘国卿 黎光南[1,2,3] 

机构地区：[1]安徽医科大学临床药理所 [2]中国药科大学 [3]云南省药物研究所

出　　处：《时珍国医国药》1999年第7期492-493,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：研究九子参总皂甙对小鼠中枢神经系统的作用。光电法测定小鼠自发活动，戊巴比妥钠用于观察协同作用，戊四氮电休克法研究抗惊厥作用，热板法测定镇痛作用。结果表明九子参总甙属皂甙类，对中枢神经系统有抑制作用，可减少小鼠自发活动，协同戊巴比妥催眠并有一定的镇痛作用，无对抗戊四氮和电休克惊厥作用，还能提高小鼠的耐缺氧能力，小鼠灌胃的ＬＤ５０为１．６５ｇ／ｋｇ。To investigate the central nervous effects of total glycosides (TG) of silene aprica in mice, methods of photocells technique for measurement of spontaneous activity, pentobarbital sodium for observation of sedation, anticonvulsant for study of anticonvulsant activities, were tested against convulsions induced by cardiazol and electroshock activities, hot plate method was for analgesic activity were used. Results: TG was belong to saponins and had depressive activities to central nervous system.TG inhibited significantly spontaneous activity in mice.TG was revealed to possess analgesic effect in mice to some extent and potentiated hypnotic activity of sodium pentobarbital at subthreshold dose. It was found that TG prolonged the survival time in anoxic mice and LD 50 in mice(PO) was 1.65g/kg.

关 键 词：九子参总皂甙 中枢抑制 镇痛 溶血指数 中药 药理 

分 类 号：R285.5[医药卫生—中药学]