原发性高血压患者血压昼夜节律变化与心率变异的相关性分析  

Relation between circadian rhythm of blood pressure and heart rate var iability in essential hypertension

作　　者：李洁[1] 李晓燕[1] 

机构地区：[1]河南省新乡医学院第三附属医院,453003

出　　处：《中国全科医学》2001年第5期354-355,共2页Chinese General Practice

摘　　要：目的 探讨原发性高血压患者的血压昼夜节律变化与心率变异的关系。方法 本研究采用动态血压检测技术和心率变异性检测技术，对正常人及不同高血压组进行相关性 比较研究 。结果 高血压组昼夜血压变化程度下降（P＜0.01）；高血压组 心率变异程度的24小时的正常 RR间期标准差(SDNN)、24小时的5分钟正常RR间期标准差均值(SDNNI)、24小时的5分钟平均R R间 期标准差(SDANNI)、相邻RR间期差值的均方根(rMSSD)、相邻正常RR间期差值大于50ms的心 搏数所占百分比(pNN50)明显下降（P＜0.05），高血压节律消失，心率变异(HRV)各项 指标显著下降。结论 提示高血压患者血压升高、HRV减低及血压昼夜 节律消失具有内在联系，高血压存在自主神经功能障碍，自主神经损害程度与高血压病情有 关。Objective To study the relation in heart rate variability（HRV）and its circadian rhythm in patients with essential hyper tension（EHT）.Methods 24 hours Holter electrocardiogram（H EM）and HRV were recorded in 68 patients with EHT and in 43 normotensive subject s.Alternations in HRV indexes of time domain and circadian rhythm changes of bl ood pressure were analyzed.Results Circadian rhythm changes and all HRV indexes in EHT group decreased as compare with those in control gro up（P＜0.01).HRV indexes decreased obviously in group of circadian rhythm disappearing.Conclusion Patients with EHT have abnormal mo dulation of the autonomic nervous system,the degree related to the state of EHT .Both HRV and circadian rhythm were decreased.Blood pressure uprising，circadi an changes disappearing and HRV decreasing have internal relation.

关 键 词：原发性高血压 心率变异 昼夜节律 动态血压 

分 类 号：R544.1[医药卫生—心血管疾病]