新型正性肌力药物维那利酮对犬的循环呼吸功能的影响  

Influences of New Synthetic Drug Vesnarinone on Circulatory and Respiratory Function of Dogs

作　　者：周祖玉[1] 蓝庭剑[1] 查忠斌 王用芬 杨正菀 

机构地区：[1]华西医大基础医学院生理学教研室 [2]华西医大药学院药理学教研室

出　　处：《华西医科大学学报》1991年第2期137-139,共3页Journal of West China University of Medical Sciences

基　　金：国家攻关资助项目

摘　　要：作者探讨了我校合成的新型强心药维那利酮(OPC-8212)对犬循环和呼吸的效应。实验结果:OPC-8212使犬颈总动脉流量显著增加;对血压、心率和呼吸三项指标均无明显影响。表明OPC-8212在整体动物心脏具有正性肌力效应而不具频率效应。有可能成为一种理想的新型强心剂。The purpose of this studywas to investigate the influences of ves-narinone, newly synthesized in the Schoolof Pharmacy, West China University ofMedical Sciences in 1985, on the circulato-ry and respiratory functions of dogs. Eightdogs were anesthetized with 3% sodiumpentobarbital. Vesnarinone (2mg/kg), di-methyl sulphoxide (the solvent which wasneeded to prepare solution of OPC-8212),and 0.9% NaCl (normal control) was givenseparately according to the arrangment ofLatin square. The ECG, blood flow,bloodpressure and respiration were measuredand recorded for 1-15 minutes. Vesnarinoneincreased the blood flow in the commoncarotid artery with no significant changesin blood pressure.heart rate, or respiration.These results suggest that OPC-8212 haspositive inotropic effect but no effect onthe heart rate in anesthetized dogs.

关 键 词：维那利酮 心电图 呼吸 

分 类 号：R972.1[医药卫生—药品]