血清T_3、T_4水平及T_3/T_4比率对预测抗甲状腺药物治疗Graves病预后的价值  

The Evaluation of Serum T_3、T_4 and T_3/T_4 Ratio in Predicting the Outcome of Graves' Disease by Antithyroid Drugs

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作  者:魏松全[1] 梁荩忠[1] 李秀钧[1] 承永明[1] 梁正路[2] 李进前[2] 王全林 许淑惠[3] 

机构地区:[1]华西医科大学附一院内分泌科 [2]华西医科大学附一院核医学科 [3]华西医科大学附一院检验科

出  处:《华西医学》1991年第3期258-261,共4页West China Medical Journal

摘  要:118例Graves病初发患者,用他巴唑治疗6月,停药后随访1年,51例缓解,67例复发。结果表明,治前的血清T_3、T_3/T_4比率及治疗结束时的T_3,在复发组与缓解组之间均有统计学差异(P<0.0005,0.005及0.025).而血清T_4,无论治前或治末,均无统计学差别(P>0.05).血清T_3/T_4比率是否与预后有关,其实质是取决于血清T_3,尤其是治前的血清T_3。118 new patients with Graves' disease were treated by methimazole for 6 months and follow-up for another 12 months. The initial dose was 30 mg/d. Bisochemical euthyroidism was achieved within 1-3 months after taking medicine and maintenance dose was given until cessation of the treatment. The results of 1 year follow-up after the withdrawal of drugs showed that of 118 patients, 67 had relapsed, with a recurrence rate of 56.8%, the remaining 51 (43.2%) were in remission. The serum T_3 before and at the end of treatment and T3/T4 ratio before therapy were significantly different between the groups of relapse and remission (p<0.0005, 0.025 and 0.005 respectively), but no significant difference in serum T3/T4 ratio at the end of therapy. The serum T3/T4 ratio is an unstable index and was affected by serum levels of T3 and T4, but serum T3 level before antithyroid drug therapy is a rather reliable parameter to predicting the outcome of hyperthyroidism due to Graves' disease

关 键 词:甲状腺肿 T3/T4比率 预后 

分 类 号:R581.107[医药卫生—内分泌]

 

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