骨质疏松症的生态遗传学系列研究:前臂骨密度连锁的染色体区域  

Serial ecogenetical studies on osteoporosis:chromosome regions linked to forearm bone mineral density

作　　者：王国英[1] 牛天华[2] 洪秀梅[2] 杨建华[2] 吴涤[2] 王朝曦[1] 方治安[2] 王滨燕[2] 

机构地区：[1]北京大学生态遗传与生殖卫生研究中心,100883 [2]安徽医科大学

出　　处：《中国骨质疏松杂志》2001年第2期97-99,共3页Chinese Journal of Osteoporosis

摘　　要：目的　为了确定前臂骨密度的遗传因子 ,对来源于 96个核心家庭的 2 18名后代进行了常染色体基因组扫描 ,旨在研究前臂骨密度与染色体的连锁证据。方法　应用荧光标记引物对36 7个常染色体基因组微卫星生物标记物进行基因型测定 ,应用pDXA法测定前臂近端和远端的骨密度。结果　前臂骨密度与D2S2 141,D2S140 0和D2S40 5 ,以及前臂远端骨密度与D13S788和D13S80 0具有连锁关系。结论　在中国人群中经性别、年龄调整后的前臂骨密度与第 2和 13号染色体某些区域相关。Objective To search systematically for chromosomal regions containing genes that regulate bone mineral density(BMD),we scanned the entire autosomal genome among 218 individuals from 96 nuclear families collected from Anqing. Methods\ 367 microsatellite polymorphic markers were genotyped by using fluorescein labelled primer,and forearm BMD was measured by pDXA. Results\ Linkage analysis showed the evidences of linkage between markers D2S2141,D2S1400,D2S405,D13S788 and D13S800 and forearm BMD. Conclusion\ A couple of chromosome 2 and 13 regions may be linked to the adjusted forearm BMD in the Chinese population.

关 键 词：骨质疏松症 骨密度 微卫星生物标记物 染色体 生态遗传学 

分 类 号：R681[医药卫生—骨科学]