亚低温治疗重度弥漫性轴索伤的临床研究  

A clinical study of moderate hypothermia treatment of acute severe diffuse axonal injury

作　　者：王维平[1] 任海军[1] 董家军[1] 

机构地区：[1]兰州医学院附属二院神经外科,甘肃兰州730030

出　　处：《创伤外科杂志》2001年第2期91-92,共2页Journal of Traumatic Surgery

摘　　要：目的 旨在探讨亚低温对重度弥漫性轴索伤（ＤＡＩ）的治疗作用及患者颅内压、预后的关系。方法 本组观察了８０例重度弥漫性轴索伤，在常规治疗的同时，对６０例行亚低温治疗。８０例重度ＤＡＩ患者分为亚低温和常温两组，所有患者均行颅内压监护５～７天。全部患者于伤后３个月行ＧＯＳ评分判断预后。结果 在亚低温组，其颅内压明显低于对照组（Ｐ＜０．０５）；亚低温组的死亡率为２６．７％，而常温治疗组为５５％（Ｐ＜０．０５）。结论 重度ＤＡＩ后，不仅应及时诊断，而且要尽早应用亚低温治疗、尽早降温。亚低温治疗有明显降低颅内压的疗效。亚低温治疗可以明显提高重度ＤＡＩ患者的生存率和生存质量，降低ＤＡＩ的死亡率和伤残率。Objective To study the therapeutie effect of moderate hypothermia on acute severed diffuse axonal injury(DAI). Methods Sixty patients were treated by moderate hypothermia. Twenty cases were controls with normal temperature. Results The results showed ICP of patients in group of for hypothermia treatment obviously lower compared to the controls(P < 0.05). The mortality in treating group and controls was 26.7% and 55% , respectively(P <0.05). Conclusion Moderate hypothemia treatment can signficantly reduce ICP of patients with severe DAI and improve their prognosis.

关 键 词：弥漫性轴索伤 亚低温治疗 颅内压 预后 颅脑损伤 

分 类 号：R651.15[医药卫生—外科学]