ACTH及睾酮对低氧小鼠红细胞生成的诱导效应  

Evoked Effects on Erythropoiesis in Mice with Chronic Hypoxia by ACTH and Testosterone Treatment

作　　者：孟庆瑜[1] 曲立文[1] 孟宪法[1] 

机构地区：[1]大连大学医学院预防医学教研室,大连116622

出　　处：《中国公共卫生》2001年第5期400-401,共2页Chinese Journal of Public Health

基　　金：辽宁省教委立项课题

摘　　要：目的　观察促肾上腺皮质激素 (ACTH)和睾酮 (T)对低氧小鼠红细胞生成的影响。方法　应用低压舱 (0 42atm ,2 2h/d ,9days) ,分别给小鼠注射促红细胞生成素 (EPO ,2 0 0u/kg·d ,ip) ,ACTH(2 5u/d ,SC) ,T(2 5mg/d ,im) ,皮质醇 (0 5mg/d ,SC) ,检测血清EPO和红细胞比容 (Hct)。结果　低氧早期骨髓对EPO高度敏感 ,持续低氧使敏感性降低。与同期单纯低氧组比较 ,注射ACTH或T使Hct显著增加 (注射皮质醇无影响 ) ,血清EPO均未见升高。Objective To observe the effects of adrenocorticotropin(ACTH) and testosterone(T) on erythropoiesis in mice with chronic hypoxia.Methods The mice with had been kept in hypobaric chamber(0 42atm,22h/d,9days),were administered erythropoietin(EPO,200u/kg·d,ip),ACTH(2 5u/d,sc),T(2 5mg/d,im),cortisol(0 5mg/d,sc) respectively,examined the level of serum EPO and hematocrit(Hct).Results The erythropoiesis of bone marrow were very sensitive to the EPO stimulus early,sensitivety decreased gradually by EPO treatment during countinously hypoxia.As compared with simply hypoxic group simultaneously,the Hct could be markdly increased by ACTH or T(it did not caused by cortisol),but the serum EPO did not elevated respectively.Conclusion Evoked effects on erythropoiesis exist in mice with chronic hypoxia by ACTH or T treatment.

关 键 词：促红细胞生成素 促肾上腺皮质激素 睾酮 红细胞比容 低氧 

分 类 号：R331.141[医药卫生—人体生理学]