血脉通胶囊的毒性实验研究  

The study of Xue-Mai-Tong-Jiao-Nang on toxin

作　　者：谢娟 黄能慧[2] 李诚秀[2] 李玲贵 

机构地区：[1]贵州省卫生干部进修学校,贵阳550001 [2]阳医学院药理教研室

出　　处：《贵州医药》2001年第5期410-412,共3页Guizhou Medical Journal

摘　　要：目的观察连续给予血脉通胶囊后由于积蓄可能对机体产生的毒性反应 ,为拟定人用安全剂量提供参考。方法给小鼠按 2 0g/kg、2 2g/kg和 2 5g/kg剂量一天灌胃给药二次 ,观察药物的急性毒性。按 0 39g/kg、0 975g/kg、1 95g/kg(相当于临床用量的 10、2 5、5 0倍 )给大鼠连续灌胃 90天 ,观察大鼠的一般状况 ,试验结束时进行血液学、血液生化及病理检查。结果未见动物异常反应及死亡 ,小鼠最大耐受量达 5 0g/kg(相当于人用量的 12 82倍 )。大鼠连续给药 90天及停药后 15天 ,体重增长基本一致 ,主要组织的脏器系数、血常规及血液生化指标均在正常范围内 ,与对照组比较差异无显著意义 (P >0 0 5 )。主要脏器的肉眼尸检及病理组织学镜检也未见明显病理改变。结论血脉通胶囊是一种低毒和安全的药物。Objective To investigate the effect of Xue-Mai-Tong-Jiao-Nang (XMTJN) on acute toxin and chronic toxin in mice and rats.Methods Mice were given XMTJN (20、22 and 25g/kg ) by gavage, twice one day, the mice were observed 7 days after gavage XMTJN. Rats were received XMTJN (0.39、0.98 and 1.95g/kg) for 12 weeks by gavage. Observe the action changes and death of the rats. Serum and main organs were examined after 12 weeks.Results Mice weren’t obtained the maximum lethal dose. The maximum tolerance dose of the mice was 50g/kg (1282 times of the dose for adult). The general condition of mice and rats were normal during experiment, without death and abnormal reaction. It was shown that blood routine serum biochemistry and pathology were normal range.Conclusion XMTJN is a lower toxin and safe medicine.

关 键 词：血脉通胶囊 急性毒性 长期毒性 实验研究 

分 类 号：R268.2[医药卫生—中医外科学] R285.5[医药卫生—中医学]