丙型肝炎病毒感染者血清病毒含量与肝细胞损伤关系的研究  

The study of the relationship between the concentration of serum hepatitis C virus RNA and hepatocyte injury in patients with hepatitis C virus infection

作　　者：崔荣辉[1] 戴二黑[1] 和玉平[1] 马艾[1] 陈黎明[1] 

机构地区：[1]石家庄市第五医院,050021

出　　处：《河北医药》2001年第5期328-329,共2页Hebei Medical Journal

摘　　要：目的　探讨HCVRNA含量与丙型肝炎的临床分型及丙氨酸转氨酶 (ALT)的关系。方法　采用荧光定量聚合酶链反应 (PCR)技术检测了 10 4例HCV感染者血清HCVRNA含量。结果　10 4例HCV感染者血清HCVRNA含量为 10 3～ 10 7拷贝 ml之间。慢性肝炎中度和轻度患者血清HCVRNA含量为 (3 .2± 9.5 )× 10 6 和 3 .9× 10 5± 1.1× 10 6 拷贝 ml(P <0 .0 5 )。血清HCVRNA水平高者ALT异常率显著高于低水平患者。结论　血清HCVRNA含量与肝细胞损伤程度有一定相关性 。Objective To study the relationship among the amount of hepatitis C virus RNA(HCV RNA),clinical types of hepatitis C as well as the level of alanine aminotransferase(ALT).Methods The concentration of HCV RNA was detected in 104 patients with HCV infection by means of quantitative polymerase chain reaction technique which was based on a Amplisensor assay.Results The amounts of serum HCV RNA in 104 patients with HCV infection were 10 3～10 7 copies/ml.The amount of serum HCV RNA in patients with middle degree and light degree of chronic hepatitis was (3.2±9.5)×10 6 and 3.9×10 5±1.1×10 6 copies/ml(P<0.05) respectively.The abnormal rate of ALT in patients with high level of HCV RNA was higher than that in patients with low level of HCV RNA.Conclusion The amount of serum HCV RNA is associated with the degree of hepatocyte injury.It is further demonstrated that HCV can directly induce hepatocyte injury.

关 键 词：丙型肝炎病毒 定量聚合酶链反应 丙型肝炎 肝细胞损伤 

分 类 号：R512.63[医药卫生—内科学]